ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) Antikörper

Antigen: ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2)

Synonyme: DD, DAR, ATP2B, SERCA2, FLJ20293, FLJ38063, MGC45367, DKFZp686P0211, KIAA4195, D5Wsu150e, mKIAA4195, 9530097L16Rik, Serca2, SercaII, dar, atp2b, serca2, ca-p60a, MGC52615, ATP2A2, SERCA2A

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Schwein, Kaninchen, Ratte (Rattus)

Applikation: Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN151703

Produktbeschreibung

Weitere Bezeichnung: ATP2A2 / SERCA2

Gen-ID: 488, 488

Swiss-Prot: NP_7337651

Immunogen: The epitope recognized by this antibody maps to a region between residue 475 and 525of human ATPase, Ca++ transporter, cardiac muscle, slow twitch 2 using the numberinggiven in entry NP_733765.1 (GeneID 488).

Beschreibung: Sarcoplasmic/endoplasmic reticulum Calcium-ATPase 2 (SERCA2) is amagnesium-dependent pump that catalyzes the hydrolysis of ATP and translocatescalcium from the cytosol to the sarcoplasmic reticulum lumen. There are 2 SERCA2isoforms that differ in the 3’ UTR. The SERCA2A isoform is highly expressed in heartand slow twitch skeletal muscle and is important to the regulation of the contraction andrelaxation cycle, while the SERCA2B isoform is expressed in smooth muscle and adultepidermis. SERCA2 is also known as ATP2A2, ATP2B, DAR, DD, and MGC45367. Alternate Names: anti-ATP dependent calcium pumps antibody, anti-ATP2A2 antibody, anti-ATP2Bantibody, anti-ATPase Ca++ transporting cardiac muscle slow twitch 2 antibody,anti-Ca++ transporting cardiac muscle slow twitch 2 antibody, anti-Calcium pump 2antibody, anti-Calcium-transporting ATPase sarcoplasmic reticulum type slow twitchskeletal muscle isoform antibody, anti-DAR antibody, anti-Darier disease antibody,anti-DD antibody, Endoplasmic reticulum class 1/2 Ca(2+) ATPase antibody,anti-MGC45367 antibody, anti-Sarcoplasmic or endoplasmic reticulum calcium ATPantibody, anti-Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 antibody,anti-SERCA 2 antibody,anti- SERCA2 antibody, anti-SR Ca(2+)-ATPase 2 antibody.

Spezifität: ABIN151703 reacts with SERCA2. Species Reactivity: Human, Rat, rabbit, and pig. Other species have not been tested. Localization: Endoplasmic reticulum + Sarcoplasmic reticulum membrane protein.

Anwendungen

Applikationshinweise: Suggested working dilutions: immunoprecipitation 1 to 4 ul,Western Blot 1:1,000 to 1:5,000. Positive Controls: Tissue from aorta from various species.

Konzentration: 1 mg/ml

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8. Preservative: 0.09% Sodium Azide.

Lagerung: Store at 4C. Do not freeze.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2) antibody

Publikationen

Publikationen: Emter, McCune, Sparagna et al.: "Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats." in: American journal of physiology. Heart and circulatory physiology, Vol. 289, Issue 5, pp. H2030-8, 2005 (PubMed).

Luckey, Mansoori, Fair et al.: "Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males." in: American journal of physiology. Heart and circulatory physiology, Vol. 292, Issue 2, pp. H838-45, 2007 (PubMed).

Leatherbury, Yu, Chatterjee et al.: "A novel mouse model of X-linked cardiac hypertrophy." in: American journal of physiology. Heart and circulatory physiology, Vol. 294, Issue 6, pp. H2701-11, 2008 (PubMed).

Prasad, Inesi: "Effects of thapsigargin and phenylephrine on calcineurin and protein kinase C signaling functions in cardiac myocytes." in: American journal of physiology. Cell physiology, Vol. 296, Issue 5, pp. C992-C1002, 2009 (PubMed).