Serotonin (5-HT) Antikörper
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| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Immunhistochemie (Gefrierschnitte) (IHC (fro)), Immunhistochemie (Paraffinschnitte) (IHC (p))
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| Produktnummer |
ABIN151521 |
| Menge |
50 µl |
| Preis |
350,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Immunogen
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Serotonin coupled to bovine serum albumin with paraformaldehyde.
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Format
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Serum
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Beschreibung
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Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine neurotransmitter synthesisedin serotonergic neurons in the central nervous system and enterochromaffin cells in thegastrointestinal tract. Serotonin plays an important part in the biochemistry ofdepression, migraine, bipolar disorder and anxiety. It is also believed to be influential onsexuality and appetite. 5-HT is generally thought not to be released from synapticterminal buttons in the manner of classical neurotransmission but from serotonergicvaracosities into the extra neuronal space. From here it is free to diffuse over a relativelylarge region of space (>20 Degreem) and activate 5-HT receptors located on thedendrites, cell bodies and presynaptic terminals of adjacent neurons. Serotonergicaction is terminated primarily via uptake of 5-HT from the synapse. This is through thespecific monoamine transporter for 5-HT, 5-HT reuptake transporter, on the presynapticneuron. The pharmacology of 5-HT is extremely complex, with its actions beingmediated by a large and diverse range of 5-HT receptors.Ab16007 may be a useful tool for characterization of carcinoids.In a study of 48 cases of adenomas and carcinoid tumours of the middle ear, theantibody labelled tumour cells in 12 cases (25%). In 1 case of carcinoid tumour of themiddle ear, the antibody labelled tumour cells. In a study of 43 cases of bronchialcarcinoid tumours, the antibody labelled tumour cells in 13 cases (30%). Cells labelledby the antibody display a cytoplasmic staining pattern. Alternate Names: anti-5 HT 5A antibody, anti-5 HT antibody, anti-5 HT5A antibody, anti-5hydroxytryptamine antibody, anti-5HT antibody.
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Spezifität
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Species Reactivity: Cross-reacts with Human and Rat. Not yet tested in other species. Localization: Cytoplasmic and Secreted.
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Applikationshinweise
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Suggested working dilutions: immunohistochemistry 1/100 - 1/200,Immunohistochemistry-Paraffin 1/100 - 1/200,Immunohistochemistry-Frozen 1/100 - 1/200
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Buffer
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1% BSA, Whole Serum. Preservative: 15mM Sodium Azide.
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Lagerung
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Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.
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Forschungsgebiet
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Hormone
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Serotonin (5-HT)", Typ "Antikörper" finden
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Wirte
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Kaninchen (10), Ziege (2), Maus (2), Ratte (2), Schaf (2)
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Reaktivitäten
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Human (7), Säugetiere (6), Ratte (Rattus) (4), Alle Spezies (2), Maus (2), Meerschweinchen (1), Kaninchen (1), Xenopus laevis (1)
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Applikationen
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Immunhistochemie (Gefrierschnitte) (IHC (fro)) (12), Immunfluoreszenz (IF) (10), Immunhistochemie (Paraffinschnitte) (IHC (p)) (8), Enzyme Immunoassay (EIA) (2), Immunhistochemie (IHC) (1)
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