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Antikörper
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anti-Superoxide Dismutase 2 / SOD2 Antikörper
Superoxide Dismutase 2 / SOD2 Antikörper
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| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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 Alternativen Rind (Kuh), Hund, Huhn, Meerschweinchen, Hamster, Human, Affe, Maus, Schwein, Kaninchen, Ratte (Rattus), Schaf, Xenopus laevis
Human (43), Ratte (Rattus) (22), Maus (20), Hamster (6), Affe (6), Kaninchen (6), Schaf (6), Xenopus laevis (6), Huhn (5), Rind (Kuh) (5), Hund (5), Meerschweinchen (5), Schwein (5), Fruchtfliege (Drosophila melanogaster) (3), Säugetiere (1)
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Applikation
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Alternativen Immunhistochemie (Gefrierschnitte) (IHC (fro)), Enzyme Immunoassay (EIA), Immunpräzipitation (IP), Western Blot (WB)
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| Produktnummer |
ABIN151490 |
| Menge |
50 µl (1.0 mg/ml) (Varianten) |
| Preis |
350,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Gen-ID
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6648, 20656, 24787
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Immunogen
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Full length protein (Rat).
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Beschreibung
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Superoxide dismutase (SOD) is responsible for the elimination of cytotoxic activeoxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogenperoxide (1, 2, 3). There are three SOD isoenzymes in mammalian cells. They are:extracellular SOD (EC SOD), copper and zinc-containing SOD (CuZn SOD) andmanganese-containing SOD (Mn SOD, SOD-2). The CuZn form contains Cu and Znions and exists as a 32 kDa dimer in the cytosol. Mn SOD is an 80 kDa tetramer thatcontains Mn ion and resides in the mitochondrial matrix. Mn SOD is a tumor necrosisfactor (TNF)-inducible enzyme that protects cells from NFmediated apoptosis (4) viasuperoxide anion detoxification and the subsequent regulation of apoptosis throughcytochrome c release and the modulation of the redox state of the mitochondria (6). MnSOD has also been shown to be a tumor suppressor in human breast cancer (7).Overexpression of this enzyme protects neurons from NMDAand nitric oxide-inducedneurotoxicity. Alternate Names: anti-IPO B antibody, anti-Manganese SOD antibody, anti-Manganese superoxidedismutase antibody, anti-SOD-2 antibody, anti-Superoxide dismutase [Mn] mitochondrialprecursor antibody, anti-Superoxide dismutase 2 mitochondrial antibody,anti-Superoxide Dismutase 2 antibody.
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Spezifität
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Detects 25kDa protein, corresponding to the molecular mass of Mn superoxidedismutase (SOD) on SDS-PAGE immunoblots. Species Reactivity: Cross reacts with Human, Rat, Mouse, Bovine, Canine, Chicken, Drosophila,Guinea Pig, Pig, Hamster, Monkey, Rabbit, Sheep and Xenopus. Localization: Mitochondrial matrix.
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Applikationshinweise
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Positive Controls: Rat Brain Tissue Extract.
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Konzentration
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1.0 mg/ml
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Buffer
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PBS (pH7.0), 50% glycerol. Preservative: Sodium Azide
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Lagerung
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Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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Forschungsgebiet
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Inflammation, Enzyme, Metabolismus
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Superoxide Dismutase 2 / SOD2", Typ "Antikörper" finden
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Wirte
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Maus (21), Kaninchen (19), Ziege (5), Schaf (1)
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Reaktivitäten
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Human (43), Ratte (Rattus) (22), Maus (20), Hamster (6), Affe (6), Kaninchen (6), Schaf (6), Xenopus laevis (6), Huhn (5), Rind (Kuh) (5), Hund (5), Meerschweinchen (5), Schwein (5), Fruchtfliege (Drosophila melanogaster) (3), Säugetiere (1)
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Applikationen
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Western Blot (WB) (37), Immunpräzipitation (IP) (20), Enzyme Immunoassay (EIA) (14), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (10), ELISA (Detektionsantikörper) (4), Immunhistochemie (Paraffinschnitte) (IHC (p)) (4), ELISA (1), Durchflusszytometrie (FACS) (1), Immunfluoreszenz (IF) (1)
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