Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta) Antikörper

Antigen: Heat Shock Protein 90 alpha/beta (HSP90 alpha/beta)

Klonalität: Monoklonal (AC88)

Wirt: Maus

Reaktivität: Vogel, Caenorhabditis elegans (C. elegans), Fisch, Säugetiere

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro)), Durchflusszytometrie (FACS), Immunfluoreszenz (IF), Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN151472

Produktbeschreibung

Weitere Bezeichnung: Heat Shock Protein 90 / HSP90 (alpha + beta)

Gen-ID: 3320, 15519, 299331

Immunogen: Achlya ambisexualis (water mold) Hsp90.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: AC88

Beschreibung: In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b whichare encoded by separate genes. These ubiquitous and highly conserved proteinsaccount for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerfulnetwork of chaperones to fight the deleterious consequences of protein unfoldingcaused by nonphysiological conditions. However, in the absence of stress, Hsp90 is anecessary component of fundamental cellular processes such as hormone signaling andcell cycle control. In this context several key regulatory proteins such as steriodreceptors, cell cycle kinases involved in signal transduction and p53 have beenidentified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitorfor morphological evolution by buffering widespread variation, which may affectmorphogenic pathways. Alternate Names: anti-Heat Shock Protein 90 antibody.

Spezifität: Ab13492 recognises both Hsp90 alpha and beta. It reacts with the rodent glucocorticoidreceptor and with proliferation potential proteins (P2PS) with apparent molecularmasses of 30-40 kDa, which are associated with the 30-40S substructures of nuclearhnRNP complexes and share an epitope in common with Hsp90. Species Reactivity: Cross-reacts with Human, Mouse, Rat, beluga, Cow, C. elegans, Chicken, Dog, Fish(brook trout, carp, chinook salmon, chum salmon, medaka, rainbow trout), Guineapig, Hamster, lobster, Monkey, Mussel, Pig, Rabbit, Scallop, Sheep and water mold.Notyet tested in other species. Localization: Cytoplasmic.

Anwendungen

Applikationshinweise: Immunoprecipitation 4 ug/ml,Western Blot 1 ug/ml

Konzentration: 1.0 mg/ml

Buffer: 50% Glycerol, PBS, 0.1mM PMSF. pH 7.2. Preservative: No Preservative.

Lagerung: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar