Tumor Protein P53 Binding Protein 1 (TP53BP1) Antikörper

Antigen: Tumor Protein P53 Binding Protein 1 (TP53BP1)

Synonyme: p202, 53BP1, FLJ41424, MGC138366, Trp53bp1, TP53BP1, MGC160112

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Durchflusszytometrie (FACS), Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN151311

Produktbeschreibung

Weitere Bezeichnung: TP53BP1

Gen-ID: 7158

Swiss-Prot: NP_0056481

Immunogen: Immunogen for this antibody was a phosphorylated synthetic peptide, whichrepresented a portion of human p53 Binding Protein 1 (GeneID 7158) around serine 25according to the numbering given in entry NP_005648.1.Phosphorylated:Ser25.

Beschreibung: P53-binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putativesubstrate of ATM kinase. Upon DNA damage, it is phosphorylated and relocalizes to thepresumptive sites of damage, specifically, double-strand breaks. This also suggests arole in DNA repair, maintaining genomic stability. Alternate Names: anti-53BP1 antibody, anti-53BP-1 antibody, anti-TP53BP1 antibody, anti-Tumor Proteinp53 Binding Protein 1 antibody.

Spezifität: Species Reactivity: Human and Mouse.

Anwendungen

Applikationshinweise: Suggested working dilutions: flow cytometry / FACS analysis 1.5mcg/ml,immunoprecipitation 1 to 4 mcg/mg of lysate,Western Blot 1:1000-1:10000

Konzentration: 0.2 mg/ml

Buffer: Tris-buffered Saline containing 0.1% BSA. Preservative: 0.09% Sodium Azide.

Lagerung: Store at 4C. Do not freeze.

Forschungsgebiet: Transkriptionsfaktoren

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody

anti-Tumor Protein P53 Binding Protein 1 (TP53BP1) antibody (Image 2)

Publikationen

Publikationen: Kang, Lee, Hoan et al.: "Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage." in: The Journal of biological chemistry, Vol. 284, Issue 15, pp. 9845-53, 2009 (PubMed).