X-ray Repair, Complementing Defective, Repair in Chinese Hamster (XRCC5) Antikörper

Antigen: X-ray Repair, Complementing Defective, Repair in Chinese Hamster (XRCC5)

Synonyme: KU80, KUB2, Ku86, NFIV, KARP1, KARP-1, FLJ39089

Klonalität: Monoklonal (5D5-8)

Wirt: Maus

Reaktivität: Human

Applikation: Western Blot (WB)

Produktnummer: ABIN151029

Produktbeschreibung

Weitere Bezeichnung: XRCC5 / Ku80 / Ku86

Gen-ID: 7520

Swiss-Prot: P13010

Immunogen: HeLa whole cell extracts.

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: 5D5-8

Beschreibung: Eukaryotic cells contain an abundant nuclear protein, Ku, which was initially discoveredas an autoantigen. Ku is a heterodimer of 70 and 80 kDa subunits which binds to DNAends and other alterations in double-stranded DNA including hairpins, nicks and gaps. Ku plays a role in DNA repair as an essential subunit of DNA-dependent protein kinase(DNA-PK) that phosphorylates certain transcription factors (Sp1, Oct-1 and p53). Kutargets DNA-PK to DNA. The Ku/DNA-PK complex might provide a structuralframework for holding broken chromosomes together during repair. Ku plays a role inmany diverse processes including cell signaling, proliferation, DNA repair, replication,transcriptional activation and apoptosis (2-4). Alternate Names: anti-ATP dependent DNA helicase II 80 kDa subunit antibody, anti-ATP dependent DNAhelicase II 86 Kd subunit antibody, anti-CTC box binding factor 85 kDa antibody,anti-CTC85 antibody, anti-CTCBF antibody, anti-DNA repair protein XRCC5 antibody,anti-KARP1 antibody, anti-Ku86 autoantigen related protein 1 antibody, anti-NFIVantibody, anti-Nuclear factor IV antibody, anti-Thyroid lupus autoantigen antibody,anti-TLAA antibody, anti-Xray repair complementing defective repair in Chinese hamstercells 5 antibody.

Spezifität: This antibody is specific for Ku 85 subunit. Species Reactivity: Human. Other species have not been tested.

Anwendungen

Applikationshinweise: Suggested working dilutions: Western Blot 1/500

Konzentration: 0.2 mg/ml

Buffer: PBS. Preservative: 0.05% Sodium Azide.

Lagerung: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Nash, Chen, Salganik et al.: "Identification of cellular proteins that interact with the adeno-associated virus rep protein." in: Journal of virology, Vol. 83, Issue 1, pp. 454-69, 2008 (PubMed).

Heemers, Regan, Schmidt et al.: "Androgen modulation of coregulator expression in prostate cancer cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 4, pp. 572-83, 2009 (PubMed).