S-100 Antikörper

Antigen: S-100

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro))

Produktnummer: ABIN150447

Produktbeschreibung

Weitere Bezeichnung: S100

Immunogen: Recombinant protein encoding human S100 protein.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: S100 belongs to the family of calcium binding proteins such as calmodulin and troponin C. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. S100A is composed of an alpha and beta chain whereas S100B is composed of two beta chains. S100 protein may function in stimulation of Ca2+ induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. Immunoreactive S100 protein localizes in the cytoplasm and nuclei of astrocytes, Schwanns cells, ependymomas and astrogliomas. Ganglion cells do not stain for S100 protein. S100 can be detected in almost all benign naevi and malignant melanocytic tumours of the skin, and in Lang

Anwendungen

Applikationshinweise: IHC: Use at a dilution of 1/100 for 10 min at room temperature. No special pretreatment is required for histochemical staining offormalin/paraffin tissues. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Reinheit: Immunogen affinity purified

Buffer: Preservative: Sodium AzideConstituents: BSA, 10mM PBS. pH 7.4.

Lagerung: Store at 4C. Aliquot and store at -20C long-term.

Forschungsgebiet: Zellzyklus

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-S-100 antibody