ASIC1 beta / ACCN2 Antikörper

Antigen: ASIC1 beta / ACCN2

Klonalität: Polyklonal

Wirt: Meerschweinchen

Reaktivität: Ratte (Rattus)

Applikation: Immunhistochemie (Gefrierschnitte) (IHC (fro))

Produktnummer: ABIN148275

Produktbeschreibung

Immunogen: Synthetic peptide: AGSELDEGDDSPRDLV, corresponding to amino acids 3-18 of Rat ASIC beta.

Format: Serum

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Proton-gated channels expressed by sensory neurons are of particular interest because low pH causes pain. Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sensory neurons. ASIC-beta, an ASIC splice variant contains a unique N-terminal 172 aa, as well as unique 5 and 3 untranslated sequence. ASIC-beta, unlike ASIC and DRASIC, is found only in a subset of small and large diameter sensory neurons and is absent from sympathetic neurons or the central nervous system. ASIC-beta forms a functional channel with electrophysiological properties distinct from ASIC and DRASIC. The pH dependency and sensitivity to amiloride of ASIC-beta is similar to that described for ASIC, but unlike ASIC, the channel is not permeable to calcium, nor are ASIC-beta-mediated currents inhibited by extracellular calcium. The unique distribution of ASIC-beta suggests that it may

Anwendungen

Applikationshinweise: IHC-Fr: Use at a dilution of 1/1000. Staining was blocked by preabsorption with the cognate peptide. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Reinheit: Whole antiserum

Buffer: Preservative: 0.05% Sodium AzideConstituents: Whole Serum

Lagerung: Store at 4 C. Aliquot and store at -20 C long-term.

Beschränkungen: Nur für Forschungszwecke einsetzbar