A Kinase (PRKA) Anchor Protein 12 (AKAP12) Antikörper

Antigen: A Kinase (PRKA) Anchor Protein 12 (AKAP12)

Synonyme: AKAP250, FLJ20945, FLJ97621, DKFZp686M0430, DKFZp686O0331, Srcs5, SSeCKS, Tsga12, AI317366, AKAP12A, AKAP12B, AKAP12G, AKAP12, esr1, sb:cb27, wu:fb72g12, wu:fc21c03, si:ch73-192g21.1

Klonalität: Polyklonal

Wirt: Schaf

Reaktivität: Ratte (Rattus)

Applikation: Immunpräzipitation (IP), Western Blot (WB)

Produktnummer: ABIN148235

Produktbeschreibung

Weitere Bezeichnung: AKAP12

Immunogen: Full length native protein (purified) (Rat).

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: SSeCKS (Src Suppressed C Kinase Substrate) is a major protein kinase C substrate with tumor suppressor activity in models of src- and ras-induced oncogenic transformation. SSeCKS regulates actin-based cytoskeletal and tissue architecture, as well as kinases such as protein kinase C (PKC), protein kinase A (PKA) and calmodulin. Additionally, SSeCKS, has been implicated in the formation of migratory processes and cell migration during embryogenesis. Rat SSeCKS shares extensive homology with human Gravin, an autoantigen in myasthenia gravis that encodes kinase scaffolding functions and whose expression pattern in fibroblasts and nerves suggests a role in cell motility.

Anwendungen

Applikationshinweise: IP: Use at a concentration of 2-5 ug/ml. WB: Use at a concentration of 2-5 ug/ml. Predicted molecular weight: 172 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Konzentration: 1 mg/ml

Reinheit: Protein A purified

Buffer: Preservative: 0.08% Sodium AzideConstituents: PBS

Forschungsgebiet: Chromatin und nukleäre Signaltransduktion, Zellzyklus, Kinasen/Phosphatasen, Neurologie

Beschränkungen: Nur für Forschungszwecke einsetzbar