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Antikörper
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anti-Activin A Receptor, Type IIB (ACVR2B) Antikörper
Activin A Receptor, Type IIB (ACVR2B) Antikörper
| Antigen |
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| Synonyme |
FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, ACTRIIB, ActR-IIB, MGC116908, ActRIIB, MGC118477, actr2b, actrIIb, wu:fj97d11, ACVR2B, Acvr2b, actriib, MGC89569, actr-iib |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Enzyme Immunoassay (EIA), Neutralisierung (Neut), Western Blot (WB)
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| Produktnummer |
ABIN148175 |
| Menge |
25 µg (0.1 mg/ml) (Varianten) |
| Preis |
330,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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Activin receptor type 2B (ACVR2B)
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Immunogen
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Recombinant fragment (Human).
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Isotyp
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IgG (Passende Sekundärantikörper)
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Beschreibung
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Activin, a disulfide-linked homodimeric protein is secreted by Sertolicells in the testis and granulosa cells in the ovary. In early studies, this peptide was thought to be an inhibin and not recognized as a unique compound. Activins and inhibins are members of the TGF-beta superfamily due to amino acid homology with respect to the conservation of 7 of the 9 cysteine residues common to all TGF-beta forms. Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits have been cloned (mammalian beta A, beta B, beta C, beta E, and Xenopus beta D). The activin/inhibin nomenclature reflects the subunit composition of the proteins: activin A (beta A-beta A), activin B (beta B-beta B), activin AB (beta B-beta A), inhibin A (alpha-beta A) abd inhibin B (alpha-beta B). Activins have a wide range of biological activities including mesoderm induction neural cell d
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Spezifität
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Based on ELISA, this antibody exhibits approximately 15 % cross-reactivity with recombinant human activin receptor IA. In immunoblotting, this antibody shows no cross-reactivity with recombinant human activin receptor IIA.
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Applikationshinweise
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ELISA: Use at a concentration of 0.5-1.0 ug/ml. Neut: Used at a concentration of 1-3 ug/ml this antibody will block 50 % of the binding of 30 ng/ml recombinant human activin A to immobilized recombinant human activin receptor IIB/Fc chimera (100 ul of a 0.5 ug/ml solution coating each well) in an ELISA assay. WB: Used at a concentration of 0.1 ug/ml to 0.2 ug/ml this antibody detects human activin receptor IIB at approximately 20 ng/lane under reducing and non-reducing conditions.. Predicted molecular weight: 58 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Konzentration
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0.1 mg/ml
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Reinheit
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Immunogen affinity purified
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Buffer
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Preservative: NoneConstituents: PBS
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Activin A Receptor, Type IIB (ACVR2B)", Typ "Antikörper" finden
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Wirte
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Kaninchen (37), Ziege (9), Maus (5), Schaf (2)
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Reaktivitäten
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Human (43), Maus (12), Ratte (Rattus) (7), Hund (5), Huhn (3), Rind (Kuh) (3), Schwein (1)
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Applikationen
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Western Blot (WB) (50), Enzyme Immunoassay (EIA) (20), Immunhistochemie (Paraffinschnitte) (IHC (p)) (16), ELISA (7), Immunhistochemie (IHC) (5), Immunpräzipitation (IP) (3), ELISA (Detektionsantikörper) (2), Dot Blot (Dot) (1), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (1)
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Epitope
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N-Term (3), C-Term V474 (1), Center N153 (1), Center N99 (1), Center R147 (1)
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