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Amphiregulin (AREG) Antikörper
| Antigen | Amphiregulin (AREG) |
| Synonyme | AR, SDGF, CRDGF, MGC13647, Sdgf, AREG, AREGB, MGC152310 |
| Klonalität | Polyklonal |
| Wirt |
 Alternativen Kaninchen |
| Reaktivität |
Alternativen Human, Maus |
| Applikation |
Alternativen Immunpräzipitation (IP)
|
| Produktnummer | ABIN148161 |
| Menge | 0.5 ml (1 mg/ml) |
| Preis | 360,00 € Zzgl. Versandkosten €20,00 und MWSt |
| Lieferung nach |
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| Verfügbarkeit | Lieferung in 7 bis 10 Werktagen |
Produktbeschreibung
| Weitere Bezeichnung | Amphiregulin |
| Immunogen | A synthetic 19 mer peptide, corresponding to amino acids 8-26 (VKPPQNKTESENTSDKPKR) from the secretedamphiregulin of human origin. |
| Isotyp | IgG (Passende Sekundärantikörper) |
| Beschreibung | Amphiregulin binds to EGF Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84 amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252 amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGF alpha, AR, HB EGF, cripto 1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas. |
Anwendungen
| Applikationshinweise | Immunoprecipitation (with protein A, native): use at a concentration of 10ug / mg of lysate. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. |
| Konzentration | 1 mg/ml |
| Reinheit | Protein A purified |
| Buffer | 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide |
| Lagerung | Refrigerate at 4 C. Do not freeze. |
| Forschungsgebiet | Krebs, Wachstumsfaktoren |
| Beschränkungen | Nur für Forschungszwecke einsetzbar |
Alternativen
Alternativen zu Antigen "Amphiregulin (AREG)", Typ "Antikörper" finden
| Wirte | Kaninchen (27), Maus (2) |
| Reaktivitäten | Human (29), Maus (25), Ratte (Rattus) (20), Rind (Kuh) (17), Pferd (17), Hund (16), Kaninchen (16), Schaf (16), Schwein (3) |
| Applikationen | Durchflusszytometrie (FACS) (18), Immunfluoreszenz (IF) (18), Western Blot (WB) (7), Immunpräzipitation (IP) (6), Immunhistochemie (Paraffinschnitte) (IHC (p)) (5), ELISA (3), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), ELISA (Detektionsantikörper) (1), Enzyme Immunoassay (EIA) (1), Immunoelectron Microscopy (IEM) (1) |
| Konjugate | Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1) |
| Epitope | AA 8-26 (1) |
