ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5) Antikörper

Antigen: ADAM Metallopeptidase with thrombospondin Type 1 Motif, 5 (ADAMTS5)

Synonyme: ADMP-2, ADAMTS11, FLJ36738, ADAMTS5, ADAMTS-11, AAC2, PNAT, ADMP-1, ADAMTS-2, ADAMTS-4, KIAA0688, KIAA0366, NPI, PCINP, PCPNI, hPCPNI, ADAM-TS2, ADAMTS-3, TTP, VWFCP, C9orf8, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, METH2, ADAM-TS8, FLJ41712, ADAM-TS7, DKFZp434H204, ASMP-2, ADAMTS1, ADAM-TS5, AI481094, 9530092O11Rik, PWTSR, THSD2, CRISTIN1, FLJ14440, AW743315, 1810011L16Rik, 8430403M15Rik, E030027K14Rik, ADAMTS7B, FLJ16042, AU015154, 4831407I23Rik, D230034E10Rik, ADAM-TS4, mKIAA0688, 3830423K05, Gm710, ADAMTS4, ADAMTS13

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN147150

Produktbeschreibung

Weitere Bezeichnung: ADAMTS5

Immunogen: Synthetic peptide: KNGYQSDAKGVKTF, corresponding to amino acids 636-649 of Human ADAMTS5 with N-terminally added cysteine.

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: ADAMTS5, also known as Implantin or Aggrecanase 2, is a member of the larger family of ADAMs (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS5 (A Disintegrin And Metalloproteinase with Thrombospondin-5 motif) was first described as ADAMTS5, a protein elevated in mice during the peri-implantion period. At the same time, another group identified Aggrecanase 11, a protein elevated in arthritic synovium. The name was later changed to ADAMTS5. ADAMTS5 is expressed in human and mouse. It has been found in heart, lung, cervix, uterus, ovary, brain, cartilage, and numerous other tissues, as well as chondroblastoma cell lines. Initial observations indicated a role for ADAMTS5 in aggrecan cleavage and cartilage destruction, especially in arthritis and potentially a role in embryo implantion. ADAMTS5 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, and has been shown to efficiently cleave Aggrecan. In addition to the metall

Spezifität: Does not cross react with other ADAMTS family members.

Synonyme: ADMP-2, ADAMTS11, FLJ36738, ADAMTS5, ADAMTS-11, AAC2, PNAT, ADMP-1, ADAMTS-2, ADAMTS-4, KIAA0688, KIAA0366, NPI, PCINP, PCPNI, hPCPNI, ADAM-TS2, ADAMTS-3, TTP, VWFCP, C9orf8, vWF-CP, FLJ42993, MGC118899, MGC118900, DKFZp434C2322, METH2, ADAM-TS8, FLJ41712, ADAM-TS7, DKFZp434H204, ASMP-2, ADAMTS1, ADAM-TS5, AI481094, 9530092O11Rik, PWTSR, THSD2, CRISTIN1, FLJ14440, AW743315, 1810011L16Rik, 8430403M15Rik, E030027K14Rik, ADAMTS7B, FLJ16042, AU015154, 4831407I23Rik, D230034E10Rik, ADAM-TS4, mKIAA0688, 3830423K05, Gm710, ADAMTS4, ADAMTS13

Anwendungen

Applikationshinweise: WB: Use at a concentration of 1 ug/ml. Detects a band of 68 KDa and a second band at 50kDa in Porcine samples and bands of 85 and 68 KDa in Human samples. Depending on the extent of C-terminal processing, several smaller bands may also be seen using this antibody.

Konzentration: 1 mg/ml

Reinheit: Immunogen affinity purified

Buffer: Preservative: 0.05% Sodium AzideConstituents: PBS, 1mg/ml BSA

Lagerung: Store at 4C. Aliquot and store at -20C long-term.

Forschungsgebiet: Proteolyse / Ubiquitin, Metalloprotease, Extrazelluläre Matrix, Proteasen

Beschränkungen: Nur für Forschungszwecke einsetzbar