Apoptotic Chromatin Condensation Inducer 1 (ACIN1) Antikörper

Antigen: Apoptotic Chromatin Condensation Inducer 1 (ACIN1)

Synonyme: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus

Applikation: Western Blot (WB)

Produktnummer: ABIN146622

Produktbeschreibung

Weitere Bezeichnung: Acinus / ACIN1

Immunogen: Synthetic peptide: TRTALHGVKWPQSNPK, corresponding to amino acids 1065-1080 of Human Acinus or 307 to 322 of human AcinusS, which are identical to those of mouse Acinus (2). The selected antigenic sequence is locatednear the C-terminus of the cleaved act

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: Chromatin condensation and nuclear fragmentation(CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase-activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE (1). A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS` (2).

Spezifität: The antibody recognises three different splice forms of Acinus, designated Acinus L, Acinus S and Acinus S.The epitope is a region near the C-terminus of the cleaved active peptide p17.

Synonyme: ACN, ACINUS, fSAP152, KIAA0670, DKFZp667N107, Acn, Acinus, C79325, acinusL, acinusS, mKIAA0670, 2610036I19Rik, 2610510L13Rik, acinus, acinusb, fi14c05, wu:fe06a10, wu:fi14c05, acinusa, acinusl, wu:fb04g06, wu:fb40f03, wu:fb68h03, wu:fb80f07, wu:fc12e10, ik:tdsubc_2g5, si:zc14a17.12, xx:tdsubc_2g5, acn, MGC69430, MGC132201

Anwendungen

Applikationshinweise: WB: Use at an assay dependant dilution. Detects a band of approximately 220 kDa (predicted molecular weight: 151 kDa). Can be blocked with GTX28367 Acinus (C-term) peptide (human) Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Konzentration: 0.5 mg/ml

Reinheit: Immunogen affinity purified

Buffer: PBS with 0.02% sodium azide

Lagerung: Store at -20 C, stable for one year.

Forschungsgebiet: Zellzyklus, Apoptose/Nekrose

Beschränkungen: Nur für Forschungszwecke einsetzbar