Agrin (AGRN) Antikörper

Antigen: Agrin (AGRN)

Synonyme: Agrin, AGR, FLJ45064, AGRN, AGRIN, agrn, wu:fb57e07

Klonalität: Polyklonal

Wirt: Maus

Reaktivität: Maus, Ratte (Rattus)

Applikation: Immunfluoreszenz (IF), Western Blot (WB)

Produktnummer: ABIN145146

Produktbeschreibung

Weitere Bezeichnung: Agrin

Immunogen: Recombinant rat agrin, C-terminal construct.

Isotyp: IgG1  (Passende Sekundärantikörper)

Beschreibung: Agrin is an essential extracellular matrix component which promotes clustering of nicotinic acetylcholine receptors (nAChRs) and other proteins during development at the neuromuscular junction. Agrin, MuSK and Rapsyn are all essential components for AChR aggregation, through an unknown mechanism. The C-terminal region of agrin is released into the medium, interacts with receptors on the muscle surface and induces AChR aggregation. The central region contains two O-linked glycosylation sites and a domain homologous to domain III of laminin. The N-terminal region anchors agrin to the extracellular matrix via other basal membrane components. This region also contains a protease inhibitor domain and glycosaminoglycan attachment sites, increasing the predicted MW from 200kDa to ~600kDa.

Spezifität: Ab12358 detects all isoforms of agrin.

Anwendungen

Applikationshinweise: ICC: Use at a concentration of 2 ug/ml. WB: Use at a concentration of 2 ug/ml. Predicted molecular weight: 208.6 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Konzentration: 1 mg/ml

Reinheit: Protein G purified

Buffer: Preservative: NoneConstituents: 50% Glycerol, PBS, 0.1mM PMSF. pH 7.2

Lagerung: Store at 4 C. Aliquot and store at -20 C long-term.

Forschungsgebiet: Neurologie

Beschränkungen: Nur für Forschungszwecke einsetzbar