ATG7 Antikörper (C-Term)

Produktnummer ABIN1449608

Produktdetails anti-ATG7 Antikörper

Target: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Bindungsspezifität: AA 547-577, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Aufreinigung: Saturated Ammonium Sulfate precipitation followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide between 547~577 amino acids from the C-term of Human APG7L Genename: ATG7

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ATG7

Target: ATG7 (ATG7 Autophagy Related 7 (ATG7))

Andere Bezeichnung: APG7L / ATG7 (ATG7 Produkte)

Synonyme: APG7-LIKE antikoerper, APG7L antikoerper, GSA7 antikoerper, D8 antikoerper, UBA1B antikoerper, UBE1L antikoerper, UBE2 antikoerper, Ube1l antikoerper, 1300004C08Rik antikoerper, AO090001000744 antikoerper, atg7 antikoerper, 1810013K23Rik antikoerper, Agp7 antikoerper, Apg7l antikoerper, Atg7l antikoerper, ATAPG7 antikoerper, ATATG7 antikoerper, ATG7 antikoerper, AUTOPHAGY 7 antikoerper, AUTOPHAGY-RELATED 7 antikoerper, K15I22.10 antikoerper, K15I22_10 antikoerper, autophagy related 7 antikoerper, ubiquitin like modifier activating enzyme 7 antikoerper, ubiquitin-like modifier activating enzyme 7 antikoerper, autophagy-related protein 7 antikoerper, Autophagy-related protein 7 antikoerper, Apg7p antikoerper, ThiF family protein antikoerper, ubiquitin-like conjugating enzyme Atg7 antikoerper, ATG7 antikoerper, UBA7 antikoerper, Uba7 antikoerper, ANI_1_3368024 antikoerper, AOR_1_1338164 antikoerper, PTRG_02236 antikoerper, PAAG_00287 antikoerper, PITG_12537 antikoerper, atg7 antikoerper, Atg7 antikoerper, APG7 antikoerper

Hintergrund: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG7 functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.Synonyms: APG7-like, Autophagy-related protein 7, Ubiquitin-activating enzyme E1-like protein

Molekulargewicht: 77960 Da

Gen-ID: 10533

NCBI Accession: NP_001129503

Pathways: Response to Water Deprivation, Autophagie