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GRB2 Antikörper (N-Term)

GRB2 Reaktivität: Human, Maus, Ratte WB Wirt: Maus Monoclonal 3F2 unconjugated
Produktnummer ABIN1449302
  • Target Alle GRB2 Antikörper anzeigen
    GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 65
    • 32
    • 31
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 52
    • 10
    • 3
    Maus
    Klonalität
    • 53
    • 11
    • 1
    Monoklonal
    Konjugat
    • 46
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GRB2 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 33
    • 20
    • 12
    • 6
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse, Rat
    Aufreinigung
    Ammonium sulfate precipitation and affinity chromatography on protein A
    Immunogen
    Recombinant Ash/Grb-2
    Klon
    3F2
    Isotyp
    IgG1
    Top Product
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore with 100 μL of distilled water.
    Buffer
    PBS, 1 mg/mL Sodium azide, 10 mg/mL sucrose
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
  • Target
    GRB2 (Growth Factor Receptor-Bound Protein 2 (GRB2))
    Andere Bezeichnung
    GRB2 / ASH (GRB2 Produkte)
    Synonyme
    GRB2 antikoerper, grb2 antikoerper, AA408164 antikoerper, Ash antikoerper, ASH antikoerper, EGFRBP-GRB2 antikoerper, Grb3-3 antikoerper, MST084 antikoerper, MSTP084 antikoerper, NCKAP2 antikoerper, wu:fb18e12 antikoerper, wu:fb34e06 antikoerper, zgc:73077 antikoerper, growth factor receptor bound protein 2 antikoerper, growth factor receptor-bound protein 2 antikoerper, growth factor receptor-bound protein 2b antikoerper, GRB2 antikoerper, grb2 antikoerper, Grb2 antikoerper, grb2b antikoerper
    Hintergrund
    Grb2 (Growth factor receptor bound protein 2) also known as Ash, is a 25-28 kDa molecule composed of central Src homology (SH2) domain and SH3 domains. Grb2 associates with tyrosine phosphorylated proteins such as EGFR, PDGFR, IRS-1, Shc and Gab1 via its Sh2 domain. The SH3 domain of Grb2 binds to Sos, which stimulates the GTP binding activity of Ras, cause activation of MAP kinase and other signaling pathways. Grb2 is an adaptor protein, which does not have enzymatic activity itself. Grb2 express ubiquitously and has two isoforms.Synonyms: Growth factor receptor-bound protein 2
    Gen-ID
    2885
    NCBI Accession
    NP_002077
    UniProt
    P62993
    Pathways
    RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, EGFR Downregulation
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