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GFRA1 Antikörper (Extracellular Domain)

GFRA1 Reaktivität: Human WB Wirt: Maus Monoclonal 4G10 unconjugated
Produktnummer ABIN1449285
  • Target Alle GFRA1 Antikörper anzeigen
    GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
    Bindungsspezifität
    • 16
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-440, Extracellular Domain
    Reaktivität
    • 55
    • 37
    • 19
    • 16
    Human
    Wirt
    • 50
    • 5
    • 2
    Maus
    Klonalität
    • 52
    • 5
    Monoklonal
    Konjugat
    • 28
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GFRA1 Antikörper ist unkonjugiert
    Applikation
    • 42
    • 16
    • 15
    • 13
    • 13
    • 13
    • 10
    • 9
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Spezifität
    This antibody detects GFRα1 (60 kDa). Reacts with HCC-1500, MCF-7, but NOT with BT-20, ZR-75-1.
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human
    Aufreinigung
    Protein A agarose
    Immunogen
    Tecombinant human GFRalpha1 extracellular domain (24-440 aa)
    Klon
    4G10
    Isotyp
    IgG2b
    Top Product
    Discover our top product GFRA1 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
    Konservierungsmittel
    Without preservative
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Upon receipt, store (in aliqouts) at -20 °C.
  • Target
    GFRA1 (GDNF Family Receptor alpha 1 (GFRA1))
    Andere Bezeichnung
    GFRA1 / GDNFR-alpha (GFRA1 Produkte)
    Synonyme
    gdnfr antikoerper, ret1l antikoerper, retl1 antikoerper, trnr1 antikoerper, gdnfra antikoerper, MGC122616 antikoerper, gfr-alpha-1 antikoerper, GDNFR antikoerper, GDNFRA antikoerper, GFR-ALPHA-1 antikoerper, RET1L antikoerper, RETL1 antikoerper, TRNR1 antikoerper, GDNFRALPHA antikoerper, GFRA1 antikoerper, AU042498 antikoerper, gfralpha1a antikoerper, zgc:110129 antikoerper, GDNF family receptor alpha 1 antikoerper, glial cell line derived neurotrophic factor family receptor alpha 1 antikoerper, gdnf family receptor alpha 1a antikoerper, gfra1 antikoerper, GFRA1 antikoerper, Gfra1 antikoerper, gfra1a antikoerper
    Hintergrund
    Glial cell line-derived neurotrophic factor (GDNF) family plays a critical role in neurodevelopment and survival of central and peripheral neurons. The biological activity of GDNF family through receptor protein tyrosine kinase Ret and require a ligand specific co-receptor a (GFRa1, binds GDNF, whereas GFRa2 binds NRTN, GFRa3 binds ARTN and GFRa4 binds PSPN). Human GFRa1 is constituted from 465 amino acids and attach to the cell membrane by glycosylphosphatidylinositol (GPI) anchoring manner. It is widely accepted that homodimeric GDNF induce the complex formation of GFRa1 and further the stoichiometry of the signaling complex with GDNF2-GFRa12-Ret2, but the mechanism of complex formation remain unclear.Synonyms: GDNF family receptor alpha-1, GDNF receptor alpha, GDNFRA, GFR-alpha-1, RET ligand 1, RETL1, TGF-beta-related neurotrophic factor receptor 1, TRNR1
    Gen-ID
    2674
    NCBI Accession
    NP_001138925
    UniProt
    P56159
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