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APP Antikörper (AA 18-38)
APP
Reaktivität: Human, Maus
WB
Wirt: Maus
Monoclonal
3-00E-009
unconjugated
Produktnummer ABIN1449275
Produktdetails anti-APP Antikörper
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Target
Alle APP Antikörper anzeigen
APP
(Amyloid beta (A4) Precursor Protein (APP))
Bindungsspezifität
Alle Epitope für APP Antikörper
AA 18-38
Reaktivität
Alle Reaktivitäten für APP Antikörper
Human, Maus
Wirt
Alle Wirte für APP Antikörper
Maus
Klonalität
Alle Klonalitäten für APP Antikörper
Monoklonal
Konjugat
Alle Konjugate für APP Antikörper
Dieser APP Antikörper ist unkonjugiert
Applikation
Alle Applikationen für APP Antikörper
Western Blotting (WB)
Sequenz
LEVPTDGNAG LLAEPQIAMF C
Kreuzreaktivität (Details)
Species reactivity (tested):Human, Mouse
Aufreinigung
Protein A agarose
Immunogen
Synthetic peptide corresponding to APP695 (18-38 aa)
Klon
3-00E-009
Isotyp
IgG1
Top Product
Discover our top product APP Primärantikörper
Alternativen
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Rekonstitution
Restore with 100 μL of distilled water.
Buffer
PBS ( pH 7.2), 0.09 % NaN3, 1 % sucrose
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted (in aliquots) at -20 °C.
Details zu APP
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Target
APP
(Amyloid beta (A4) Precursor Protein (APP))
Andere Bezeichnung
Amyloid beta A4 Protein / APP (APP Produkte )
Synonyme
AAA antikoerper, ABETA antikoerper, ABPP antikoerper, AD1 antikoerper, APPI antikoerper, CTFgamma antikoerper, CVAP antikoerper, PN-II antikoerper, PN2 antikoerper, aaa antikoerper, abeta antikoerper, abpp antikoerper, ad1 antikoerper, appi antikoerper, ctfgamma antikoerper, cvap antikoerper, pn2 antikoerper, APP antikoerper, APP-like antikoerper, APPL antikoerper, Abeta antikoerper, BcDNA:GH04413 antikoerper, CG7727 antikoerper, Dmel\\CG7727 antikoerper, EG:65F1.5 antikoerper, appl antikoerper, Abpp antikoerper, Adap antikoerper, Ag antikoerper, Cvap antikoerper, E030013M08Rik antikoerper, betaApp antikoerper, app antikoerper, wu:fj34d10 antikoerper, wu:fk65e12 antikoerper, zgc:85740 antikoerper, amyloid beta precursor protein antikoerper, amyloid beta (A4) precursor protein antikoerper, beta amyloid protein precursor-like antikoerper, amyloid beta (A4) precursor protein a antikoerper, amyloid beta precursor protein L homeolog antikoerper, APP antikoerper, app antikoerper, Appl antikoerper, App antikoerper, appa antikoerper, app.L antikoerper
Hintergrund
Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques consists of 39-42 amino acids peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial earlyonset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two proteases: ß-secretase and ?-secretase. Recent study suggested that a transmembrane aspartic protease, termed ß-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II
Gen-ID
351
NCBI Accession
NP_000475
UniProt
P05067
Pathways
Caspase Kaskade in der Apoptose , EGFR Signaling Pathway , Transition Metal Ion Homeostasis , Skeletal Muscle Fiber Development , Toll-Like Receptors Cascades , Feeding Behaviour
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