IL12RB1 Antikörper (PE)

Produktnummer ABIN1449167

Produktdetails anti-IL12RB1 Antikörper (PE)

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL12RB1 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Spezifität: This antibody reacts with CD212 / IL-12R β1. For details see protocol below.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A agarose

Immunogen: B300-19 cells transfected with the vector expressing an IL-12R beta1/Tac fusion protein.

Klon: TOS

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, 0.09 % NaN3, 1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8 °C.

Details zu IL12RB1

Target: IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))

Andere Bezeichnung: CD212 / IL12RB1 (IL12RB1 Produkte)

Synonyme: Il12rb antikoerper, IL12RB1 antikoerper, IL-12R antikoerper, CD212 antikoerper, IL-12R-BETA1 antikoerper, IL12RB antikoerper, IL-12R[b] antikoerper, interleukin 12 receptor subunit beta 1 antikoerper, interleukin 12 receptor, beta 1 antikoerper, Il12rb1 antikoerper, IL12RB1 antikoerper

Hintergrund: A functional interleukin 12 receptor complex is composed of two ß-type cytokine receptor subunits, IL-12R ß1 (100 kDa) and IL-12R ß2 (130 kDa), each independently exhibiting a low affinity for IL-12. Co-expression leads to the formation of high-affinity IL-12-binding sites and reconstitution of IL-12-dependent signaling. IL-12R ß1 is a member of the hemopoietin receptor superfamily, bearing strong homology to gp130. IL-12 receptors are expressed primarily on activated T cells and natural killer (NK) cells, and activation of human PBMCs results in the up-regulation of IL-12R ß1 expression and IL-12 binding. Alternately, individuals that are genetically deficient in IL-12R ß1 produce greatly reduced IFN-? levels compared to healthy individuals. IL-12 induces tyrosine phosphorylation of a recently identified 85 kDa component of the IL-12 receptor complex that associates with the IL-12R ß1 subunit.Synonyms: IL-12 receptor beta, IL-12R-beta-1, IL-12RB1, IL12 receptor beta component, Interleukin-12 receptor beta-1 chain

Gen-ID: 3594

NCBI Accession: NP_005526

UniProt: P42701

Pathways: JAK-STAT Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation