Microphthalmia-Associated Transcription Factor (MITF) Antikörper

Antigen: Microphthalmia-Associated Transcription Factor (MITF)

Synonyme: MI, WS2A, bHLHe32, Wh, bw, mi, vit, Bhlhe32, Vitiligo, MGC124309, MGC124310, MITF, CMI9, MITF-H, MITF-M, ws2a, mitfa, MITF-A, LOC100313655, mitfb

Klonalität: Polyklonal

Wirt: Maus

Reaktivität: Rind (Kuh), Hund, Huhn, Pferd, Human, Maus, Ratte (Rattus), Xenopus laevis

Applikation: Western Blot (WB)

Produktnummer: ABIN144311

Produktbeschreibung

Weitere Bezeichnung: MITF

Immunogen: Synthetic peptide: SEARALAKERQK, corresponding to amino acids 301-312 of Human MiTF.

Isotyp: IgG1  (Passende Sekundärantikörper)

Beschreibung: MiTF is a basic helix-loop-helix-leucine zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of Mi causes Waardenburg Syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of Mi differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer Mi form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melonoma cells (but not other melanoma cell lines), as well as mast cells and heart.

Anwendungen

Applikationshinweise: WB: Use at a dilution of 1/250-1/1000. Detects a band of approximately 55 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Reinheit: Protein G purified

Buffer: Preservative: 0.02% Sodium AzideConstituents: PBS

Lagerung: Store at 4 C. Aliquot and store at -20 C long-term.

Forschungsgebiet: Transkriptionsfaktoren

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

anti-Microphthalmia-Associated Transcription Factor (MITF) antibody