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MLLT11 Antikörper (AA 41-90) (Cy3)

MLLT11 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN1417607
  • Target Alle MLLT11 Antikörper anzeigen
    MLLT11 (Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog), Translocated To, 11 (MLLT11))
    Bindungsspezifität
    • 14
    • 6
    • 1
    • 1
    • 1
    AA 41-90
    Reaktivität
    • 23
    • 3
    • 2
    Human
    Wirt
    • 22
    • 2
    Kaninchen
    Klonalität
    • 22
    • 2
    Polyklonal
    Konjugat
    • 7
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MLLT11 Antikörper ist konjugiert mit Cy3
    Applikation
    • 12
    • 12
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human
    Homologie
    Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MLLT11
    Isotyp
    IgG
    Top Product
    Discover our top product MLLT11 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    MLLT11 (Myeloid/lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog), Translocated To, 11 (MLLT11))
    Andere Bezeichnung
    MLLT11 (MLLT11 Produkte)
    Synonyme
    AF1Q antikoerper, RP11-316M1.10 antikoerper, AI839562 antikoerper, Af1q antikoerper, Zfp692 antikoerper, RGD1305525 antikoerper, fc23g02 antikoerper, si:ch211-210h11.4 antikoerper, wu:fc23g02 antikoerper, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 antikoerper, MLLT11, transcription factor 7 cofactor antikoerper, MLLT11 antikoerper, Mllt11 antikoerper, mllt11 antikoerper
    Hintergrund

    Synonyms: AF1Q, ALL1 fused gene from chromosome 1q, MLLT 11, MLLT-11, Myeloid/lymphoid or mixed lineage leukemia trithorax homolog, Drosophila translocated to 11, Protein AF1q, RP11 316M1.10.

    Background: The gene encoding the Mixed-Lineage Leukemia (MLL) proteins is located on chromosome 11q23. Chromosomal translocations involving band 11q23 result in rogue activator proteins that are associated with approximately 10 % of patients with acute lymphoblastic leukemia (ALL) and 5 % of patients with acute myeloid leukemia (AML). Most patients affected are less than 1 year of age. MLLT11, also known as mixed-lineage leukemia translocated to 11 or AF1q, is a 90 amino acid MLL fusion partner. Based on the expression patterns of MLLT11, it is thought that MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML). Also, expressed in embryonic brain cortex, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system. Finally, MLLT11 has been shown to be differentially expressed in highly metastatic cells, in comparison with non-metastatic parent cells. Such findings suggest a role of MLLT11 in tumorigenesis.

    Gen-ID
    10962
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