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Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) Antikörper

Antigen

Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B)
Synonyme KIP1, MEN4, CDKN4, MEN1B, P27KIP1, p27, Rpn4, MGC8644, Kip1, Cdki1b, sb:cb611, wu:fb63g10, wu:fb64g10, wu:fe18e03, CDKN1B
Klonalität Polyklonal
Wirt
Alternativen

Kaninchen
Reaktivität
Alternativen

Human, Maus, Ratte (Rattus)
Applikation
Alternativen Immunpräzipitation (IP), Immunhistochemie (Paraffinschnitte) (IHC (p)), Western Blot (WB)
Produktnummer ABIN140562
Menge 1 ml  (0.2 mg/ml)  (Varianten)
Preis 390,00 €   Zzgl. Versandkosten €20,00 und MWSt
Lieferung nach
Verfügbarkeit Lieferung in 7 bis 10 Werktagen

Produktbeschreibung
Anwendungen Alternativen Sekundärantikörper Varianten zurück nach oben

Weitere Bezeichnung CDKN1B / KIP1
Immunogen Synthetic peptide: AGSVEQTPKKPGLRRRQT, corresponding to C terminal amino acids 181-198 of Human p27 KIP 1
Isotyp IgG  (Passende Sekundärantikörper)
Beschreibung Cell cycle progression is regulated by cyclins and their cognate Cdks. p27 KIP 1 is a cell cycle regulatory mitotic inhibitor of cdk activity. p27 KIP 1 is a candidate tumor suppressor gene, and has been proposed to function as a possible mediator of TGF beta induced G1 arrest. p27 KIP 1 is up-regulated in response to antimitogenic stimuli. The increased protein expression of p27 results in cellular arrest by binding to cyclin/Cdk complexes such as cyclin D1/Cdk4. p27 Kip1 is regulated by phosphorylation on serine 10 (S10) and threonine 187 (T187). Phosphorylation by CDK2 on T187 results in ubiquitylation and degradation of p27 Kip 1, while phosphorylation by hKIS on S10 signals the nuclear export to the cytoplasm.
Spezifität Reacts with p27 (also designated Kip1 p27)

Anwendungen
Alternativen Sekundärantikörper Varianten zurück nach oben

Applikationshinweise IHC-Fr: Use at an assay dependent concentration. IP: Use at an assay dependent concentration. WB: Use at an assay dependent concentration. Can be blocked with GTX28015 p21 (C-term) peptide (human) . Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Konzentration 0.2 mg/ml
Reinheit IgG fraction
Buffer PBS containing 0.1% sodium azide and 0.2% gelatin
Lagerung Keep as concentrated solution, aliquot and store at 4C. Do not freeze
Forschungsgebiet Krebs, Zellzyklus
Beschränkungen Nur für Forschungszwecke einsetzbar

Alternativen
Anwendungen Sekundärantikörper Varianten zurück nach oben

Alternativen zu Antigen "Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B)", Typ "Antikörper" finden
Wirte Kaninchen (60), Maus (20), Ziege (8), Huhn (2)
Reaktivitäten Human (81), Maus (35), Ratte (Rattus) (31), Hund (5), Affe (2), Katze (1), Huhn (1), Rind (Kuh) (1)
Applikationen Western Blot (WB) (75), Immunhistochemie (Paraffinschnitte) (IHC (p)) (37), Enzyme Immunoassay (EIA) (18), Immunpräzipitation (IP) (18), ELISA (10), Immunfluoreszenz (IF) (10), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (9), Immunhistochemie (IHC) (9), ELISA (Detektionsantikörper) (5), Dot Blot (Dot) (3)
Epitope pThr187 (5), internal (2), pSer178 (2), pThr157 (2), pThr198 (2), C-Term (1), T198 (1), pS10 (1), pS178 (1), pSer10 (1), pT157 (1), pT187 (1)