UBE2J2 Antikörper (AA 1-100) (Alexa Fluor 350)

Produktnummer ABIN1398753

Produktdetails anti-UBE2J2 Antikörper (Alexa Fluor 350)

Target: UBE2J2 (Ubiquitin-Conjugating Enzyme E2, J2 (UBE2J2))

Bindungsspezifität: AA 1-100

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBE2J2 Antikörper ist konjugiert mit Alexa Fluor 350

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human UBE2J2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu UBE2J2

Target: UBE2J2 (Ubiquitin-Conjugating Enzyme E2, J2 (UBE2J2))

Andere Bezeichnung: UBE2J2 (UBE2J2 Produkte)

Synonyme: NCUBE-2 antikoerper, NCUBE2 antikoerper, PRO2121 antikoerper, 1200007B18Rik antikoerper, 2400008G19Rik antikoerper, 5730472G04Rik antikoerper, AL022923 antikoerper, Ubc6 antikoerper, Ubc6p antikoerper, zgc:162164 antikoerper, ubiquitin conjugating enzyme E2 J2 antikoerper, ubiquitin-conjugating enzyme E2J 2 antikoerper, ubiquitin-conjugating enzyme E2, J2 antikoerper, ubiquitin-conjugating enzyme E2 J2 antikoerper, ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) antikoerper, ubiquitin conjugating enzyme E2 J2 L homeolog antikoerper, UBE2J2 antikoerper, Ube2j2 antikoerper, LOC5574000 antikoerper, CpipJ_CPIJ008956 antikoerper, ube2j2 antikoerper, uce2 antikoerper, ube2j2.L antikoerper, LOC100067387 antikoerper

Hintergrund:

Synonyms: NCUBE-2, NCUBE2, Non-canonical ubiquitin-conjugating enzyme 2, UB2J2_HUMAN, UBC6, UBC6 homolog, ube2j2, Ubiquitin-conjugating enzyme E2 J2.

Background: Ubiquitination is an important molecular mechanism by which abnormal or short-lived proteins are targeted for degradation by the concerted efforts of at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2J2 (Ubiquitin-conjugating enzyme E2 J2), also known as NCUBE2 (Non-canonical ubiquitin-conjugating enzyme 2), is a 259 amino acid single pass type IV membrane protein that that belongs to the E2 ubiquitin-conjugating enzyme family and is involved in protein degradation. Localized to the membrane of the endoplasmic reticulum (ER), UBE2J2 catalyzes the attachment of ubiquitin to misfolded membrane proteins, thereby targeting them for proteasomal destruction. This ATP-dependent reaction yields AMP, a diphosphate and a ubiquitin-tagged protein and may be a method of quality control within the ER. Two isoforms of UBE2J2 exist due to alternative splicing events.

Gen-ID: 118424