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ATXN7 Antikörper (AA 301-400) (Alexa Fluor 488)

ATXN7 Reaktivität: Maus, Ratte WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 488
Produktnummer ABIN1390558
  • Target Alle ATXN7 Antikörper anzeigen
    ATXN7 (Ataxin 7 (ATXN7))
    Bindungsspezifität
    • 14
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    Reaktivität
    • 34
    • 26
    • 18
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Maus, Ratte
    Wirt
    • 47
    • 1
    Kaninchen
    Klonalität
    • 47
    • 1
    Polyklonal
    Konjugat
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ATXN7 Antikörper ist konjugiert mit Alexa Fluor 488
    Applikation
    • 37
    • 23
    • 12
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus, Ratte
    Homologie
    Human,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Ataxin 7
    Isotyp
    IgG
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  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ATXN7 (Ataxin 7 (ATXN7))
    Andere Bezeichnung
    Ataxin 7 (ATXN7 Produkte)
    Synonyme
    MGC82940 antikoerper, ADCAII antikoerper, OPCA3 antikoerper, SCA7 antikoerper, A430107N12Rik antikoerper, AI627028 antikoerper, Sca7 antikoerper, ataxin-7 antikoerper, RGD1562692 antikoerper, ataxin 7 L homeolog antikoerper, ataxin 7 antikoerper, atxn7.L antikoerper, atxn7 antikoerper, ATXN7 antikoerper, Atxn7 antikoerper
    Hintergrund

    Synonyms: Ataxin7, Ataxin-7, ADCAII, ATXN 7, OPCA III, OPCA3, SCA 7, SCA7, Spinocerebellar Ataxia 7, Spinocerebellar ataxia type 7 protein, ATX7_HUMAN.

    Background: The human ataxin-7 gene, also known as spinocerebellar ataxia 7 or SCA7, maps to chromosome 3p13-p12, has a 2,727-bp open reading frame, and encodes a 892 amino acid protein containing a nuclear localization signal and a polyglutamine tract (1,2). SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product (3,4). Ataxin-7 is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype (5). Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function (6).

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