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ERN1 Antikörper (pSer726)

ERN1 Reaktivität: Human, Maus, Ratte WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1387531
  • Target Alle ERN1 Antikörper anzeigen
    ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
    Bindungsspezifität
    • 16
    • 15
    • 15
    • 13
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer726
    Reaktivität
    • 102
    • 77
    • 73
    • 16
    • 1
    Human, Maus, Ratte
    Wirt
    • 106
    • 4
    • 3
    • 1
    Kaninchen
    Klonalität
    • 107
    • 7
    Polyklonal
    Konjugat
    • 32
    • 11
    • 10
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser ERN1 Antikörper ist unkonjugiert
    Applikation
    • 81
    • 43
    • 28
    • 25
    • 25
    • 10
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus, Ratte
    Homologie
    Dog,Cow,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic phosphopeptide derived from human IRE1a around the phosphorylation site of Ser 726
    Isotyp
    IgG
    Top Product
    Discover our top product ERN1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Jiang, Yun, Shi, Niu, Gao, Xie, Yu: "Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress." in: American journal of physiology. Cell physiology, Vol. 310, Issue 9, pp. C755-63, (2016) (PubMed).

    Xu, Su, Song, Shi, Fu, Hu, Xia, Song, Song: "Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release." in: Chemical research in toxicology, Vol. 28, Issue 6, pp. 1326-37, (2015) (PubMed).

  • Target
    ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
    Andere Bezeichnung
    IRE1a (ERN1 Produkte)
    Synonyme
    IRE1 antikoerper, IRE1P antikoerper, IRE1a antikoerper, hIRE1p antikoerper, 9030414B18Rik antikoerper, AI225830 antikoerper, C85377 antikoerper, Ire1a antikoerper, Ire1alpha antikoerper, Ire1p antikoerper, RGD1559716 antikoerper, Ern1 antikoerper, Ire1 antikoerper, Ire1b antikoerper, sb:eu1005 antikoerper, zgc:109932 antikoerper, endoplasmic reticulum to nucleus signaling 1 antikoerper, endoplasmic reticulum to nucleus signaling 2 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 1 antikoerper, serine/threonine-protein kinase/endoribonuclease IRE1 antikoerper, endoplasmic reticulum (ER) to nucleus signalling 2 antikoerper, ERN1 antikoerper, ERN2 antikoerper, Ern1 antikoerper, LOC524719 antikoerper, Ern2 antikoerper, ern1 antikoerper
    Hintergrund

    Synonyms: IRE1, IRE1P, IRE1a, hIRE1p, Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, ERN1

    Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.

    Gen-ID
    2081
    UniProt
    O75460
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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