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CD8 alpha Antikörper (PE)

CD8A Reaktivität: Maus FACS Wirt: Ratte Monoclonal 53-6-7 PE
Produktnummer ABIN135122
  • Target Alle CD8 alpha (CD8A) Antikörper anzeigen
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Reaktivität
    • 213
    • 131
    • 46
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    • 7
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    Maus
    Wirt
    • 170
    • 130
    • 112
    • 1
    Ratte
    Klonalität
    • 309
    • 100
    • 1
    Monoklonal
    Konjugat
    • 135
    • 46
    • 31
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    • 9
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    • 2
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    • 2
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    • 2
    • 1
    • 1
    • 1
    • 1
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    • 1
    • 1
    • 1
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    • 1
    Dieser CD8 alpha Antikörper ist konjugiert mit PE
    Applikation
    • 310
    • 111
    • 100
    • 69
    • 61
    • 50
    • 44
    • 25
    • 16
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    Flow Cytometry (FACS)
    Spezifität
    Mouse CD8α, Mr 32-34 kDa
    Produktmerkmale
    Rat Anti-Mouse CD8a-PE
    Immunogen
    Spleen cells or thymocyte membranes
    Klon
    53-6-7
    Isotyp
    IgG2a
    Top Product
    Discover our top product CD8A Primärantikörper
  • Applikationshinweise
    • Applications: FC - Quality tested , IHC-FS - Reported in literature , ICC - Reported in literature , IP - Reported in literature , Depletion - Reported in literature , Block - Reported in literature
    • Working Dilutions: Flow Cytometry Purified (UNLB) antibody 2 g/106 cells FITC and BIOT conjugates 2 g/106 cells AF488 conjugate 1 g/106 cells PE, APC, SPRD, PE/TXRD, CY5, PE/CY5.5, PE/CY7, 0.2 g/106 cells APC/CY5.5, APC/CY7, PACBLU, AF647, and AF700 conjugates For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
    Kommentare

    In vivo and in vitro depletion of CD8a+ cells

    Probenmenge
    1 mL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.1 mg/mL
    Buffer
    0.1 mg in 1.0 mL of PBS/Sodium azide and a stabilizing agent
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze!
    Protect conjugated products from light.

    Each reagent is stable for the period shown on the bottle label if stored as directed.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C
  • Vaziry, Silim, Bleau, Frenette, Lamontagne: "Chicken infectious anaemia vaccinal strain persists in the spleen and thymus of young chicks and induces thymic lymphoid cell disorders." in: Avian pathology : journal of the W.V.P.A, Vol. 40, Issue 4, pp. 377-85, (2011) (PubMed).

  • Target
    CD8 alpha (CD8A) (CD8a Molecule (CD8A))
    Andere Bezeichnung
    CD8a (CD8A Produkte)
    Synonyme
    cd8 antikoerper, LOC100136450 antikoerper, BB154331 antikoerper, Ly-2 antikoerper, Ly-35 antikoerper, Ly-B antikoerper, Lyt-2 antikoerper, zgc:136643 antikoerper, CD8 antikoerper, Leu2 antikoerper, MAL antikoerper, p32 antikoerper, RHACD8-4 antikoerper, CD8a molecule antikoerper, uncharacterized LOC100125537 antikoerper, CD8 alpha antikoerper, CD8 antigen, alpha chain antikoerper, T-cell surface glycoprotein CD8 alpha chain antikoerper, Cd8a antikoerper, LOC100125537 antikoerper, LOC100136450 antikoerper, CD8A antikoerper, cd8a antikoerper, LOC100126556 antikoerper
    Hintergrund
    In the mouse, CD8 exists in two forms: (i) a CD8 heterodimer composed of an chain (CD8/Lyt-2) and a chain (CD8/Lyt-3), and (ii) a homodimer of two chains. The heterodimer is found on the surface of essentially all thymocytes and the suppressor/cytotoxic subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8 without CD8. It has been suggested that CD8+- T cells mature extrathymically, while development of the CD8++ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8+ cells.
    Pathways
    T-Zell Rezeptor Signalweg
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