BCL2L1 Antikörper (AA 3-14)

Produktnummer ABIN135025

Produktdetails anti-BCL2L1 Antikörper

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Bindungsspezifität: AA 3-14

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BCL2L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Mouse/Rat/Human Bcl-xL

Produktmerkmale: Mouse Anti-Bcl-xL-UNLB

Aufreinigung: Purified

Immunogen: Bcl-xL peptide (a.a. 3-14) common to mouse and human

Klon: 2H12

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

• Applications: WB - Quality tested , IP - Reported in literature , FC - Reported in literature , IHC-PS - Reported in literature , ELISA - Reported in literature
• Working Dilutions: Immunoblotting Purified (UNLB) antibody ≤ 2 g/mL

Probenmenge: 1 mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: 0.1 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added

Konservierungsmittel: Without preservative

Handhabung: Each reagent is stable for the period shown on the bottle label if stored as directed.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C

Details zu BCL2L1

Target: BCL2L1 (BCL2-Like 1 (BCL2L1))

Andere Bezeichnung: Bcl-xL (BCL2L1 Produkte)

Synonyme: BCL-XL/S antikoerper, BCL2L antikoerper, BCLX antikoerper, BCLXL antikoerper, BCLXS antikoerper, Bcl-X antikoerper, PPP1R52 antikoerper, bcl-xL antikoerper, bcl-xS antikoerper, Bcl(X)L antikoerper, Bcl-XL antikoerper, Bcl-Xs antikoerper, Bcl2l antikoerper, BclX antikoerper, bcl-x antikoerper, Bcl-xl antikoerper, Bclx antikoerper, bcl-X antikoerper, Bcl-xL antikoerper, BCL-XL antikoerper, BCL2L1 antikoerper, bcl-XL antikoerper, bcl-x(l) antikoerper, bcl-xl/s antikoerper, bcl-xs antikoerper, bcl2l antikoerper, bclx antikoerper, bclxl antikoerper, xR11 antikoerper, bcl-xl antikoerper, blp1 antikoerper, cb1021 antikoerper, zfBLP1 antikoerper, BCL2 like 1 antikoerper, BCL2-like 1 antikoerper, Bcl2-like 1 antikoerper, BCL2-like 1 L homeolog antikoerper, bcl2-like 1 antikoerper, BCL2L1 antikoerper, Bcl2l1 antikoerper, bcl2l1 antikoerper, bcl2l1.L antikoerper

Hintergrund: Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellular systems. It plays a key role in tissue and organ development as well as in adult tissues during cell turnover. Apoptosis can be induced by a variety of internal and external stimuli including growth factor deprivation, cytokine treatment, antigen-receptor engagement, cell-cell interactions, irradiation and glucocorticoid treatment. Bcl-2 and one of its homologues, Bcl-xL, protect cells from apoptosis, while other homologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought to be essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2, other results suggest that the formation of heterodimers may not be necessary for this death-repressing activity.

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling