B-Catenin (pSer45) Antikörper

Antigen: B-Catenin

Synonyme: ARM, Beta-cat, Beta-catenin, EG:86E4.6, beta-cat-arm, l(1)2Bv, l(1)G0192, l(1)G0234, l(1)G0410, l(1)arm, t12687 ALR Dm, DmelCG11579, CG11579

Epitope: pSer45

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human, Maus, Ratte (Rattus)

Applikation: Western Blot (WB)

Produktnummer: ABIN130955

Produktbeschreibung

Weitere Bezeichnung: Phospho-b-Catenin (Ser45)

Isotyp: IgG, Ig Fraction  (Passende Sekundärantikörper)

Beschreibung: Catenin is one of the key downstream effectors in the Wnt signaling pathway. It has been implicated to play an important role in early embryonic development and tumorigenesis. ß-catenin can be destabilized by GSK-3ß or other kinases by phosphorylating it at serines 33, 37, 45 and threonine 41. Mutations of these phosphorylation sites in ß-catenin have been found in many tumor cell lines.

Spezifität: Recognizes Phospho-ß-Catenin in human, mouse, and rat cell lysates. The antibody recognizes the 90 kDa ß-catenin phosphorylated on Ser45 from human, mouse, and rat origin. It does not recognize unphosphorylated ß-catenin, a-catenin or .-catenin.

Anwendungen

Applikationshinweise: The antibody can be used for Western blot analysis (1 µg/ml). However, the optimal conditions should be determined individually.

Buffer: Supplied as 100 µg (0.5 mg/ml) rabbit polyclonal anti-phospho-ß-Catenin antibody in phosphate- buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide.

Forschungsgebiet: Phospho-Antikörper

Beschränkungen: Nur für Forschungszwecke einsetzbar