Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C) Antikörper

Antigen: Tumor Necrosis Factor Receptor Superfamily, Member 13C (TNFRSF13C)

Synonyme: BAFFR, CD268, BAFF-R, MGC138235, RGD1560810, TNFRSF13C

Klonalität: Monoklonal (8A7)

Wirt: Maus

Applikation: Western Blot (WB), Immunhistochemie (IHC), Durchflusszytometrie (FACS)

Produktnummer: ABIN130728

Produktbeschreibung

Weitere Bezeichnung: BAFF/BLyS Receptor (R3)

Immunogen: This antibody was purified from hybridoma (clone 8A7) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell NS-1 with BALB/c mouse splenocyte immunized with human BAFF-R/BR3 transfectant.

Isotyp: IgG2a  (Passende Sekundärantikörper)

Klon: 8A7

Beschreibung: BAFF (B cell-activating factor belonging to the TNF family) is a membrane protein expressed by dendritic cells, monocytes, macrophages, follicular dendritic cells, activated T cells, activated neutrophils, and malignant B cells. BAFF, also known as BLyS (B lymphocyte stimulator), is a potent B cell growth factor. Proteolytic cleavage can result in the release of a soluble trimeric BAFF which binds to the BAFF-R/BR3, BCMA and TACI. BAFF-R/BR3 is the principal receptor for B cell survival and responses induced by BAFF.

Spezifität: This antibody reacts with human BAFF-R/BR3 by flow cytometry.

Anwendungen

Applikationshinweise: Western blotting: 1 µg / mL. Immunoprecipitation: Not tested. Immunohistochemistry: 5 µg / mL Heat treatment is necessary for paraffin embedded sections. Microwave oven: 2 times for 10 minutes each in citrate buffer (pH 6.5). Flow Cytometry: 5 µg / mL (final concentration)

Konzentration: 1 mg/ml

Buffer: 100 µg IgG in 100 µL P BS containing 50% glycerol, pH 7.2. Contains no preservatives.

Forschungsgebiet: Apoptose/Nekrose, Rezeptoren

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Immunohistochemical detection of BAFF-R/BR3 on paraffin embedded sections (left) and mock transfected cells (right)

Publikationen

Publikationen: Mackay, Schneider, Rennert et al.: "BAFF AND APRIL: a tutorial on B cell survival." in: Annual review of immunology, Vol. 21, pp. 231-64, 2003 (PubMed).