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LRP1 Antikörper

LRP1 Reaktivität: Human, Maus, Ratte, Kaninchen, Hamster WB, FACS, IF, IHC (fro) Wirt: Maus Monoclonal 8B8 unconjugated
Produktnummer ABIN125957
  • Target Alle LRP1 Antikörper anzeigen
    LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
    Reaktivität
    • 101
    • 54
    • 52
    • 10
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte, Kaninchen, Hamster
    Wirt
    • 93
    • 27
    • 1
    Maus
    Klonalität
    • 86
    • 35
    Monoklonal
    Konjugat
    • 44
    • 13
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser LRP1 Antikörper ist unkonjugiert
    Applikation
    • 64
    • 45
    • 37
    • 32
    • 21
    • 15
    • 14
    • 14
    • 13
    • 9
    • 9
    • 7
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    8B8 specifically reacts with the 85 kDa β-chain of human LRP/α2MR which is expressed in a restricted spectrum of cell types (for a recent review cf. Herz & Strickland). A strong immunohistochemical reaction is seen in hepato-cytes, tissue macrophages, subsets of neurones and as-trocytes in the central nervous system, fibroblasts, smooth muscle cells, and monocyte-derived foam cells in athero-sclerotic lesions in the arterial wall. The antibody can also be used for the characterization of a subset of myelo-monocytic subtypes of chronic and acute leukemia (CD 91).
    Aufreinigung
    Affinity Chromatography on Protein A.
    Immunogen
    Human LRP/alpha2MR
    Klon
    8B8
    Isotyp
    IgG1
    Top Product
    Discover our top product LRP1 Primärantikörper
  • Applikationshinweise
    Immunofluorescence. Immunohistochemistry: 1/20. Flow Cytometry. Immunoblotting.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    Restore in 1 mL dist. water.
    Buffer
    Final Solution contains PBS buffer, pH 7.4 containing 0.5 % BSA without preservatives.
    Konservierungsmittel
    Without preservative
    Handhabung
    This product is photosensitive and should be protected from light
    Lagerung
    4 °C
    Informationen zur Lagerung
    Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
  • Target
    LRP1 (Low Density Lipoprotein Receptor-Related Protein 1 (LRP1))
    Andere Bezeichnung
    CD91 / LRP1 (LRP1 Produkte)
    Synonyme
    A2MR antikoerper, APOER antikoerper, APR antikoerper, CD91 antikoerper, IGFBP3R antikoerper, LRP antikoerper, LRP1A antikoerper, TGFBR5 antikoerper, A2mr antikoerper, AI316852 antikoerper, Lrp antikoerper, LRP-1 antikoerper, LDL receptor related protein 1 antikoerper, prolow-density lipoprotein receptor-related protein 1 antikoerper, low density lipoprotein receptor-related protein 1 antikoerper, LRP1 antikoerper, Lrp1 antikoerper, LOC100414789 antikoerper
    Hintergrund
    Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.Synonyms: A2MR, APOER, APR, Alpha-2-macroglobulin receptor, Apolipoprotein E receptor, Prolow-density lipoprotein receptor-related protein 1
    Gen-ID
    4035
    NCBI Accession
    NP_002323
    UniProt
    Q07954
    Pathways
    Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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