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Antikörper
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anti-Platelet Glycoprotein Ib alpha Chain (GP1BA) Antikörper
Platelet Glycoprotein Ib alpha Chain (GP1BA) Antikörper
| Antigen |
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| Synonyme |
BSS, GP1B, CD42B, MGC34595, CD42b-alpha, GPIba, GPIbalpha |
| Klonalität |
Monoklonal (HIP1) |
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Wirt
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Reaktivität
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Applikation
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 Alternativen Durchflusszytometrie (FACS), Immunhistochemie (Gefrierschnitte) (IHC (fro)), Funktionale Studien (Func)
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| Produktnummer |
ABIN125719 |
| Menge |
0.1 mg (1 mg/ml) (Varianten) |
| Preis |
190,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 3 bis 5 Werktagen |
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Weitere Bezeichnung
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CD42b
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Immunogen
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Peripheral blood mononuclear cells of a patient suffering with CLL.
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Format
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Azide Free
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Isotyp
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IgG1 (Passende Sekundärantikörper)
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Klon
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HIP1
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Beschreibung
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CD42b (GPIb alpha) composes together with GPIb beta, GPIX and GPV the GPIb-IX-Vreceptor complex critical in the process of platelet-rich thrombus formation by tethering theplatelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed ata site of vascular injury, as well as to thrombin, coagulation factors XI and XII, highmolecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domainof CD42b by its interactions also contributes to metastasis.
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Spezifität
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The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoproteinexpressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composedin a disulfide linked heterodimer (CD42b/c, 160 kDa), CD42b/c forms a noncovalentcomplex with CD42a and CD42d.HLDA IV, WS Code P 40
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Applikationshinweise
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Functional Application: The antibody HIP1 inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF)to platelets and ristocetin-induced platelet agglutination.
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Konzentration
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1 mg/ml
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Reinheit
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> 95% (by SDS-PAGE)
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Reinigung
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Purified from ascites by protein-G affinity chromatography.
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Buffer
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Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 µ m filter sterilized.
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Lagerung
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Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.
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Forschungsgebiet
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CD Antigene, Oberflächenrezeptoren der Immunzellen
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Platelet Glycoprotein Ib alpha Chain (GP1BA)", Typ "Antikörper" finden
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Wirte
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Maus (29)
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Reaktivitäten
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Human (29), Primaten (2)
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Applikationen
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Durchflusszytometrie (FACS) (27), Funktionale Studien (Func) (5), Western Blot (WB) (5), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (4), Immunfluoreszenz (IF) (2), Immunhistochemie (IHC) (2), Blockierende Antikörper (Inhibition) (1), Immunoassay (IA) (1), Immunhistochemie (Paraffinschnitte) (IHC (p)) (1)
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Konjugate
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FITC (4), PE (4), APC (3), Biotin (2), PerCP (2), RPE (1), SPRD (1)
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