CD58 (CD58) Antikörper

Antigen: CD58 (CD58)

Synonyme: LFA3, LFA-3, FLJ23181, FLJ43722

Klonalität: Monoklonal (MEM-63)

Wirt: Maus

Reaktivität: Human, Schwein

Applikation: Durchflusszytometrie (FACS), Immunpräzipitation (IP), Western Blot (WB), Funktionale Studien (Func)

Produktnummer: ABIN125698

Produktbeschreibung

Weitere Bezeichnung: CD58

Immunogen: NALM-6 human pre-B cell line

Format: Azide Free

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: MEM-63

Beschreibung: CD58 (LFA-3) is an immunoglobulin family adhession molecule expressed by bothhematopoietic and non-hematopoietic cells (often on antigen presenting cells) and servingas ligand of CD2. This interaction is important for T cell-mediated immunity. CD58 isexpressed in transmembrane form and in GPI-anchored form, the later is constitutivelyassociated with protein kinases whereas the transmembrane form activates kinase activityupon triggering. CD58 is a powerful tool for detection of minimal residual disease in acutelymphocytic leukemia, and for evaluation of liver damage related with hepatitis B.

Spezifität: The antibody MEM-63 reacts with CD58 (LFA-3), a 40-70 kDa glycoprotein distributed overmany tissues, leukocytes, erythrocytes, endothelial cells, epithelial cells and fibroblasts.HLDA VI, WS Code AS A047

Anwendungen

Applikationshinweise: Western Blotting. Application note: Non-reducing conditions. Functional Application: The antibody MEM-63 inhibits CD2/CD58 interactions.

Konzentration: 1 mg/ml

Reinheit: > 95% (by SDS-PAGE)

Reinigung: Purified from hybridoma culture supernatant by protein-A affinity chromatography.

Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4, 0.2 µ m filter sterilized.

Lagerung: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Forschungsgebiet: CD Antigene, Oberflächenrezeptoren der Immunzellen

Beschränkungen: Nur für Forschungszwecke einsetzbar