Prostate Specific Membrane Antigen (PSMA) Antikörper

Antigen: Prostate Specific Membrane Antigen (PSMA)

Klonalität: Monoklonal (3-00E-006)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN125529

Produktbeschreibung

Immunogen: BALB/C mice were injected with LNCaP membrane preparation and Immunoaffinity purified PSMA.

Isotyp: IgG1

Klon: 3-00E-006

Spezifität: Prostate specific membrane antigen (PSMA) is a 750 amino acid type II membrane glycoprotein. PSMA is expressed in normal and malignant prostatic epithelium and in a subset of non-prostatic tissues. PSMA expression has been shown to correlate with the progression of prostate cancer, with highest levels expressed in hormone-refractory and metastatic disease. PSMA expresses in neovasculature of a variety of non-prostatic solid tumors.

Anwendungen

Applikationshinweise: Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 to 60 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 1 mM EDTA buffer, pH 9.0 prior to immunostaining. Positive Control: Prostate carcinoma. Cellular localization: Cytoplasmic and/or membrane

Konzentration: 100ug/ml approximately

Buffer: This antibody is supplied as tissue culture supernatant containing BSA and sodium azide as preservative.

Lagerung: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Forschungsgebiet: Zell-/Gewebemarker, Krebs

Beschränkungen: Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.