»
Antikörper
»
anti-MutS Homolog 6 (E. Coli) (MSH6) Antikörper
MutS Homolog 6 (E. Coli) (MSH6) Antikörper
| Antigen |
|
| Synonyme |
GTBP, HSAP, HNPCC5, cb326, wu:fb36c12, MSH6, LOC100227810 |
| Klonalität |
Monoklonal (44) |
|
Wirt
|
|
|
Reaktivität
|
|
|
Applikation
|
Western Blot (WB) (35), Immunfluoreszenz (IF) (25), Immunhistochemie (Paraffinschnitte) (IHC (p)) (23), Durchflusszytometrie (FACS) (18), Immunpräzipitation (IP) (13), ELISA (12), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (10), Enzyme Immunoassay (EIA) (5), Gel Shift (GS) (3), Elektromobilitäts-Experimente (EMSA) (2), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunhistochemie (IHC) (2), Immunzytochemie (ICC) (1), Immunoelectron Microscopy (IEM) (1)
|
| Produktnummer |
ABIN125520 |
| Menge |
500ul (100ug/ml approximately) (Varianten) |
| Preis |
264,42 € Zzgl. Versandkosten €20,00 und MWSt
|
| Lieferung nach |
|
| Verfügbarkeit |
Lieferung in 5 Werktagen |
|
Weitere Bezeichnung
|
MSH6
|
|
Immunogen
|
Synthetic human MSH6 peptide.
|
|
Format
|
Ig-fraction
|
|
Isotyp
|
IgG1 (Passende Sekundärantikörper)
|
|
Klon
|
44
|
|
Spezifität
|
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. This antibody cross reacts with mouse, rat and dog.
|
|
Applikationshinweise
|
Titer/Working Dilution: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Positive Control: Tonsil, colon carcinoma. Cellular localization: Nuclear Other Applications: immunoprecipitation and Western blotting (1:100-500).
|
|
Konzentration
|
100ug/ml approximately
|
|
Buffer
|
This antibody is supplied as affinity purified immunoglobulin liquid containing sodium azide as preservative.
|
|
Lagerung
|
Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.
|
|
Beschränkungen
|
Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.
|
Alternativen zu Antigen "MutS Homolog 6 (E. Coli) (MSH6)", Typ "Antikörper" finden
|
Wirte
|
Kaninchen (41), Maus (28), Ziege (4)
|
|
Reaktivitäten
|
Human (69), Maus (29), Ratte (Rattus) (24), Hund (5), Kaninchen (2), Rind (Kuh) (1)
|
|
Applikationen
|
Western Blot (WB) (35), Immunfluoreszenz (IF) (25), Immunhistochemie (Paraffinschnitte) (IHC (p)) (23), Durchflusszytometrie (FACS) (18), Immunpräzipitation (IP) (13), ELISA (12), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (10), Enzyme Immunoassay (EIA) (5), Gel Shift (GS) (3), Elektromobilitäts-Experimente (EMSA) (2), Immunhistochemie (formalinfixierte Schnitte) (IHC (f)) (2), Immunhistochemie (IHC) (2), Immunzytochemie (ICC) (1), Immunoelectron Microscopy (IEM) (1)
|
|
Konjugate
|
Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1), RBITC (1)
|
Alternativen 
