Myeloid Cell Leukemia (Mcl-1) Antikörper

Antigen: Myeloid Cell Leukemia (Mcl-1)

Klonalität: Monoklonal (RC13)

Wirt: Maus

Reaktivität: Human

Applikation: Immunhistochemie (Paraffinschnitte) (IHC (p))

Produktnummer: ABIN125476

Produktbeschreibung

Immunogen: BALB/C mice were immunized with recombinant human Mcl-1 protein corresponding to amino acid 1-327.

Format: Purified

Isotyp: IgG1 kappa  (Passende Sekundärantikörper)

Klon: RC13

Spezifität: This antibody stains with a 42 kD protein. Myeloid cell leukema-1 (Mcl-1) is a member of bcl-2 family, which blocks programmed cell death. The carboxy terminal of Mcl-1 and bcl-2 share significant sequence homology. Like bcl-2, Mcl-1 protein can interact with Bax, inhibiting BAX- induced cell death and promoting cell viability. Mcl-1 stains epithelial cells in a variety of tissues including prostate, breast, endometrium, epidermis, stomach, small intestine, colon and respiratory tract.

Anwendungen

Applikationshinweise: Titer/Working Dilution: This antibody may be diluted to a titer of 1:50-1:100 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Positive Control: Tonsil. Cellular localization: Nuclear, occasionally cytoplasmic Other Applications: Immunoprecipitation, Western blotting (1:100-500).

Konzentration: 100ug/ml approximately

Buffer: This antibody is supplied as purified ascites containing sodium azide as preservative.

Lagerung: Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.

Forschungsgebiet: Krebs

Beschränkungen: Für Forschungszwecke. Als CE-zertifizierter Antikörper in der Europäischen Union für In Vitro Diagnostik (IVD) zugelassen.