Tumor Protein P53 (TP53) Antikörper

Antigen: Tumor Protein P53 (TP53)

Synonyme: p53, LFS1, TRP53, FLJ92943, P53, Trp53, MGC112612, brp53, drp53, fb40d06, wu:fb40d06, zgc:111919, TP53, bbl, bfy, bhy, p44, Tp53, tp53

Klonalität: Polyklonal

Wirt: Kaninchen

Applikation: Western Blot (WB)

Produktnummer: ABIN123800

Produktbeschreibung

Weitere Bezeichnung: Tumor Supressor Protein p53

Format: Liquid

Beschreibung: P53 was identified as a tumor suppressor by showing to block the transformation and to inhibit tumor cell growth. In addition, this protein is a transcription factor capable of regulating the expression of a subset of downstream genes. Different mutations in p53 gene have been characterized in a variety of human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. alpha-p53 is an affinity-purified rabbit polyclonal antibody raised against the recombinant p53 protein.

Spezifität: Alpha-p53 reacts with the p53 protein in HeLa nuclear extract by Western blotting.

Anwendungen

Applikationshinweise: Recommended dilution range for Western blot analysis: 1:200 - 1:1000.

Lagerung: store at -80 °C, avoid freeze/thaw cycles. Shipped on dry ice. Shelf Life: 12 months.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Bennett, Hollstein, Hsu et al.: "Mutational spectra and immunohistochemical analyses of p53 in human cancers." in: Chest, Vol. 101, Issue 3 Suppl, pp. 19S-20S, 1992 (PubMed).

Hollstein, Sidransky, Vogelstein et al.: "p53 mutations in human cancers." in: Science (New York, N.Y.), Vol. 253, Issue 5015, pp. 49-53, 1991 (PubMed).

Michalovitz, Halevy, Oren: "Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53." in: Cell, Vol. 62, Issue 4, pp. 671-80, 1990 (PubMed).

Baker, Markowitz, Fearon et al.: "Suppression of human colorectal carcinoma cell growth by wild-type p53." in: Science (New York, N.Y.), Vol. 249, Issue 4971, pp. 912-5, 1990 (PubMed).

Fields, Jang: "Presence of a potent transcription activating sequence in the p53 protein." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1046-9, 1990 (PubMed).

Raycroft, Wu, Lozano: "Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene." in: Science (New York, N.Y.), Vol. 249, Issue 4972, pp. 1049-51, 1990 (PubMed).

Finlay, Hinds, Levine: "The p53 proto-oncogene can act as a suppressor of transformation." in: Cell, Vol. 57, Issue 7, pp. 1083-93, 1989 (PubMed).