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Antikörper
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anti-Vitamin D3 Receptor (VDR) Antikörper
Vitamin D3 Receptor (VDR) Antikörper
| Antigen |
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| Synonyme |
NR1I1, Nr1i1, VDR, LOC100008907, LOC100136371 |
| Klonalität |
Polyklonal |
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Wirt
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Reaktivität
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Human (31), Huhn (14), Ratte (Rattus) (12), Maus (11), Schwein (4), Hund (3), Hamster (3), Vogel (2), Rind (Kuh) (2), Amphibien (1), Fisch (1), Frosch (1), Kaninchen (1)
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Applikation
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 Alternativen Elektromobilitäts-Experimente (EMSA), Immunpräzipitation (IP), Western Blot (WB)
Western Blot (WB) (31), Immunhistochemie (Paraffinschnitte) (IHC (p)) (9), Gel Shift (GS) (8), Enzyme Immunoassay (EIA) (7), ELISA (5), Immunfluoreszenz (IF) (5), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (3), Immunpräzipitation (IP) (3), ELISA (Detektionsantikörper) (2), Immunhistochemie (IHC) (2), Chromatin-Immunopräzipitation (ChiP) (1), Dot Blot (Dot) (1), Elektromobilitäts-Experimente (EMSA) (1)
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| Produktnummer |
ABIN122845 |
| Menge |
0.1 ml (Varianten) |
| Preis |
370,00 € Zzgl. Versandkosten €20,00 und MWSt
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| Lieferung nach |
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| Verfügbarkeit |
Lieferung in 7 bis 10 Werktagen |
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Weitere Bezeichnung
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Vitamin D3 receptor / NR1I1
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Swiss-Prot
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P11473
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Immunogen
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Synthetic Peptide: E E H S K Q Y R C L S F Q P E C S M K corresponds to amino acid residues 395- 413 from human VDR
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Format
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Serum
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Beschreibung
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Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T- cell proliferation and interleukin-2 (IL-2) gene expresion, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. Alternate Names: VDR.
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Spezifität
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ABIN122845 detects vitamin D receptor (VDR) from human, mouse and rat tissues.
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Applikationshinweise
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Western blot: 1/100, Detects an ~53 kDa protein representing VDR in COS-7 cells transfected with the human gene. Gel shift: supershifts DNA fragments that contain VDR response elements, e.g., rat osteocalcin and mouse osteopontin upstream elements. Immunoprecipitation. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
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Buffer
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This antibody is supplied as liquid antiserum containing 0.05% sodium azide as preservative.
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Lagerung
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Store the antibody at -20°C. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
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Forschungsgebiet
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Vitamine
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Beschränkungen
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Nur für Forschungszwecke einsetzbar
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Alternativen zu Antigen "Vitamin D3 Receptor (VDR)", Typ "Antikörper" finden
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Wirte
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Kaninchen (16), Ratte (12), Maus (8), Ziege (6)
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Reaktivitäten
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Human (31), Huhn (14), Ratte (Rattus) (12), Maus (11), Schwein (4), Hund (3), Hamster (3), Vogel (2), Rind (Kuh) (2), Amphibien (1), Fisch (1), Frosch (1), Kaninchen (1)
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Applikationen
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Western Blot (WB) (31), Immunhistochemie (Paraffinschnitte) (IHC (p)) (9), Gel Shift (GS) (8), Enzyme Immunoassay (EIA) (7), ELISA (5), Immunfluoreszenz (IF) (5), Immunhistochemie (Gefrierschnitte) (IHC (fro)) (3), Immunpräzipitation (IP) (3), ELISA (Detektionsantikörper) (2), Immunhistochemie (IHC) (2), Chromatin-Immunopräzipitation (ChiP) (1), Dot Blot (Dot) (1), Elektromobilitäts-Experimente (EMSA) (1)
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Konjugate
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Biotin (3)
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