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Caspase 4 Antikörper (N-Term)

CASP4 Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN121890
  • Target Alle Caspase 4 (CASP4) Antikörper anzeigen
    Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
    Bindungsspezifität
    • 9
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 59
    • 34
    • 15
    • 14
    • 1
    Human, Maus
    Wirt
    • 78
    • 11
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 77
    • 15
    Polyklonal
    Konjugat
    • 55
    • 15
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser Caspase 4 Antikörper ist unkonjugiert
    Applikation
    • 75
    • 29
    • 27
    • 12
    • 9
    • 7
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    This antibody recognises an epitope within the N-terminal region (NT) of Caspase-4, otherwise known as ICH-2. This antibody detects a band of approximately 34 kDa in Ramos cell lysates (predicted precursor MWT 31 kDa).
    Aufreinigung
    Affinity Chromatography
    Immunogen
    A 16 amino acid peptide from human Caspase-4 amino terminus
    Isotyp
    IgG
    Top Product
    Discover our top product CASP4 Primärantikörper
  • Applikationshinweise
    Western Blot: 1.0 μg/mL. Immunohistochemistry on paraffin sections: 2.0 μg/mL, This product does not require protein digestion pre-treatment of paraffin embedded sections e.g. trypsin or pronase prior to staining, This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Recommended Positive Control: Spleen tissue.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, 0.02 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf Life: one year from despatch.
    Haltbarkeit
    12 months
  • Target
    Caspase 4 (CASP4) (Caspase 4, Apoptosis-Related Cysteine Peptidase (CASP4))
    Andere Bezeichnung
    Caspase-4 (CASP4 Produkte)
    Synonyme
    ICE(rel)II antikoerper, ICEREL-II antikoerper, ICH-2 antikoerper, Mih1/TX antikoerper, TX antikoerper, Casp11 antikoerper, CASP13 antikoerper, CASP1 antikoerper, CASP4 antikoerper, Caspl antikoerper, ich-3 antikoerper, Casp4 antikoerper, caspase 4 antikoerper, caspase 4, apoptosis-related cysteine peptidase antikoerper, caspase-4 antikoerper, CASP4 antikoerper, Casp4 antikoerper, LOC100731032 antikoerper
    Hintergrund
    Caspase-4, a member of the Caspase-1 subfamily of cysteine proteases, exists as an inactive pro-enzyme which undergoes proteolytic cleavage of its p30 precursor form, into smaller p20 and p10 subunits. The cellular localisation of Caspase-4 on the Endoplasmic Reticulum (ER) membrane, has resulted in this protein becoming a focus of studies in which dysfunction or stress to the ER membrane is implicated, such as Alzheimers disease and Ischemia (1, 3) and confirms the involvement of Caspase-4 as an instigator of cellular apoptosis.Synonyms: CASP4, ICE(rel)-II, ICH2, Protease ICH-2, Protease TX
    Gen-ID
    837
    UniProt
    P49662
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity
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