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CD130/gp130 Antikörper

IL6ST Reaktivität: Human FACS, EIA Wirt: Maus Monoclonal B-T2 unconjugated
Produktnummer ABIN120026
  • Target Alle CD130/gp130 (IL6ST) Antikörper anzeigen
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Reaktivität
    • 139
    • 66
    • 56
    • 20
    • 18
    • 18
    • 17
    • 4
    • 1
    • 1
    Human
    Wirt
    • 115
    • 26
    • 4
    • 2
    • 1
    Maus
    Klonalität
    • 117
    • 31
    Monoklonal
    Konjugat
    • 52
    • 15
    • 9
    • 9
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD130/gp130 Antikörper ist unkonjugiert
    Applikation
    • 99
    • 39
    • 39
    • 31
    • 28
    • 26
    • 18
    • 13
    • 10
    • 9
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
    Spezifität
    This antibody specifically recognises soluble and membrane bound gp130 receptor. This antibody has been reported to block the activity of IL-6.
    Aufreinigung
    Ion exchange chromatography
    Immunogen
    Natural soluble gp130 receptor. Spleen cells from immunised BALB/c (Iffa Credo) mice were fused with cells of the X63.Ag8.653 mouse myeloma cell line.
    Klon
    B-T2
    Isotyp
    IgG1
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  • Applikationshinweise
    ELISA. Flow Cytometry: 0.2 μg/106cells, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.09 % Sodium Azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
    Andere Bezeichnung
    CD130 / IL6ST (IL6ST Produkte)
    Synonyme
    CD130 antikoerper, CDW130 antikoerper, GP130 antikoerper, IL-6RB antikoerper, 5133400A03Rik antikoerper, AA389424 antikoerper, BB405851 antikoerper, D13Ertd699e antikoerper, gp130 antikoerper, Ac1055 antikoerper, Gp130 antikoerper, Il-6rb antikoerper, IL-6 antikoerper, interleukin 6 signal transducer antikoerper, IL6ST antikoerper, Il6st antikoerper, il6st antikoerper
    Hintergrund
    CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
    Gen-ID
    3572
    NCBI Accession
    NP_002175
    UniProt
    P40189
    Pathways
    JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
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