Integrin Alpha2b Antikörper (Biotin)

Produktnummer ABIN119840

Produktdetails anti-Integrin Alpha2b Antikörper (Biotin)

Target: Integrin Alpha2b (CD41)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Integrin Alpha2b Antikörper ist konjugiert mit Biotin

Applikation: Flow Cytometry (FACS)

Spezifität: This antibody recognizes the integrin alpha IIb subunit CD41. Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo. We recommend the use of SM2035A for use in functional studies.

Aufreinigung: Affinity Chromatography on Protein G.

Klon: MWReg30

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: Neat - 1:10, use 10 μL to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: Phosphate buffered saline containing, pH 7.4 with 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen für anti-Integrin Alpha2b Antikörper (Biotin) (ABIN119840)

Fujita, Takayama-Tsujimoto, Satoh, Gutiérrez, Aburatani, Fujii, Sarai, Bresnick, Yamamoto, Motohashi: "NF-E2 p45 is important for establishing normal function of platelets." in: Molecular and cellular biology, Vol. 33, Issue 14, pp. 2659-70, (2013) (PubMed).

Takayama, Fujita, Suzuki, Okuyama, Aiba, Motohashi, Yamamoto: "Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis." in: Molecular and cellular biology, Vol. 30, Issue 11, pp. 2668-80, (2010) (PubMed).

Perez, Desponts, Parquet, Kerr: "SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors." in: PLoS ONE, Vol. 3, Issue 10, pp. e3565, (2008) (PubMed).

Tamagawa-Mineoka, Katoh, Ueda, Takenaka, Kita, Kishimoto: "The role of platelets in leukocyte recruitment in chronic contact hypersensitivity induced by repeated elicitation." in: The American journal of pathology, Vol. 170, Issue 6, pp. 2019-29, (2007) (PubMed).

Details zu Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Andere Bezeichnung: CD41 / ITGA2B (CD41 Produkte)

Synonyme: AI172977 antikoerper, CD41 antikoerper, CD41B antikoerper, GpIIb antikoerper, alphaIIb antikoerper, BDPLT16 antikoerper, BDPLT2 antikoerper, GP2B antikoerper, GPIIb antikoerper, GT antikoerper, GTA antikoerper, HPA3 antikoerper, integrin alpha 2b antikoerper, integrin subunit alpha 2b antikoerper, Itga2b antikoerper, ITGA2B antikoerper

Hintergrund: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation. CD41 is expressed on platelets and megakaryocytes and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

Gen-ID: 16399

NCBI Accession: NP_034705

UniProt: Q9QUM0

Pathways: Integrin Complex