C-MYC Antikörper (V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian)) (C-Term) (HRP)

Details for Product anti-MYC Antibody No. ABIN119683, Anbieter: Anmelden zum Anzeigen
Antigen
  • LOC100136746
  • RNCMYC
  • c-myc
  • mMyc
  • AU016757
  • Myc2
  • Niard
  • Nird
  • bHLHe39
  • MYC
  • cmyc
  • zc-myc
  • MRTL
  • MYCC
  • c-Myc
  • C-MYC
  • CMYC
  • CMyc
  • v-myc myelocytomatosis viral oncogene homolog
  • MYC proto-oncogene, bHLH transcription factor
  • myelocytomatosis oncogene
  • MYC proto-oncogene, bHLH transcription factor a
  • v-myc myelocytomatosis viral oncogene homolog (avian)
  • LOC100136746
  • Myc
  • myca
  • MYC
Epitop
C-Term
166
121
77
46
43
29
26
18
18
16
15
15
14
10
5
5
3
3
3
2
2
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2
2
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1
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1
1
1
1
1
1
1
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1
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Reaktivität
Human
706
215
125
50
42
36
20
20
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14
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12
9
9
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6
4
4
4
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3
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1
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Wirt
Maus
377
343
29
16
8
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser C-MYC Antikörper ist konjugiert mit HRP
47
41
39
21
18
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17
14
13
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13
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12
10
5
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4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
483
244
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161
150
124
91
52
18
14
14
11
9
8
6
6
4
2
2
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
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Immunogen Synthetic peptide sequence corresponding to the C-terminal region of Human c-myc.
Sequenz AEEQKLISEE DLL
Klon 9-00E-010
Isotyp IgG1
Spezifität This antibody detects the 62 kDa c-myc gene product. SM1863HRP may also be used to detect the commonly used c-myc 'tag'.
Kreuzreaktivität (Details) Species reactivity (tested):Human.
Reinigung Affinity Chromatography on Protein G
Andere Bezeichnung C-Myc (MYC Antibody Abstract)
Hintergrund C-myc gene product is involved in the regulation of the cell cycle and cell growth. It is primarily located to the cell nucleus, but has also been shown to localised to the cytoplasm in several cell lines. Overexpression of c-myc has been reported in a wide variety of human cancers.Synonyms: c-myc tag, myc tag, myc-tag
Gen-ID 4609
NCBI Accession NP_002458
UniProt P01106
Forschungsgebiet Transcription Factors, Cancer, Cell Cycle
Pathways p53 Signalweg, Zellzyklus, Sensory Perception of Sound, Transition Metal Ion Homeostasis, Mitotic G1-G1/S Phases, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
Applikationshinweise ELISA: 1/100-1/500. Western blot: 1/100-1/500 (Non-Reducing Conditions). Detects a band of approximately 62 kDa in Colo 320HSR cell lysates. Immunohistochemistry on Frozen and Paraffin Sections: This product does not requireprotein digestion pre-treatment of paraffin sections prior to staining and does not requireantigen retrieval using heat treatment prior to staining of paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Buffer PBS, pH 7.4, 0.01 % Thimerosal, HRP Stabilizer
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Allgemeine Veröffentlichungen Spandidos, Pintzas, Kakkanas, Yiagnisis, Mahera, Patra, Agnantis: "Elevated expression of the myc gene in human benign and malignant breast lesions compared to normal tissue." in: Anticancer research, Vol. 7, Issue 6, pp. 1299-304, 1988 (PubMed).

Evan, Lewis, Ramsay, Bishop: "Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product." in: Molecular and cellular biology, Vol. 5, Issue 12, pp. 3610-6, 1986 (PubMed).

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