Huntingtin Antikörper (AA 1844-2131)

Produktnummer ABIN119306

Produktdetails anti-Huntingtin Antikörper

Target: Huntingtin (HTT)

Bindungsspezifität: AA 1844-2131

Reaktivität: Human, Maus, Kaninchen

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Huntingtin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This antibody reacts with an epitope corresponding to the HDB region (amino acids 1844-2131) of the Huntingtin protein. The combined use of Clone HDB4E10 (Cat.-No SM1661), HDC8A4 (Cat.-No SM1662) and HDA3E10 (Cat.-No SM1660) demonstrate that huntingtin is enriched in neuronal cells in the brain.

Aufreinigung: Purified

Immunogen: Recombinant protein corresponding to amino acids 1844 - 2131 of huntingtin

Klon: HDB4E10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: Clone HDB4E10 detects a 350KD band on western blots but also detects smaller degradation products of huntingtin. Immunoprecipitation. Immunohistochemistry on frozen sections. Recommended positive control tissue: Brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Huntingtin

Target: Huntingtin (HTT)

Andere Bezeichnung: Huntingtin (HTT Produkte)

Synonyme: HTT antikoerper, hd antikoerper, ZHD antikoerper, CG9995 antikoerper, Dmel\\CG9995 antikoerper, HD antikoerper, Hsap\\HD antikoerper, Htt antikoerper, dHtt antikoerper, dhtt antikoerper, SLC6A4 antikoerper, huntington antikoerper, it15 antikoerper, htt antikoerper, IT15 antikoerper, AI256365 antikoerper, C430023I11Rik antikoerper, Hd antikoerper, Hdh antikoerper, huntingtin antikoerper, HTT antikoerper, htt antikoerper, LOC373520 antikoerper, Htt antikoerper

Hintergrund: Huntington's disease (HD) is a neurodegenerative disorder caused by an expanding polyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominant neurodegeneative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years. The HD gene product is widely expressed in human tissues, with the highest level of expression in the brain. The huntingtin gene product is expressed at similar levels in patients and controls, which suggests that the expansion of the polyglutamine repeat induces a toxic gain of function perhaps through interactions with other cellular proteins. Using yeast two-hybrid system, HAP1 (huntingtin associated protein 1) has been identified, that associates with huntingtin protein. The In vitro data suggest that the association between HAP1 and huntingtin is enhanced by increasing length of glutamine repeat.Synonyms: HD, HTT, Huntington Disease Protein, IT15

Gen-ID: 3064

NCBI Accession: NP_002102

UniProt: P42858

Pathways: PI3K-Akt Signalweg, Hormone Transport, Transition Metal Ion Homeostasis, Tube Formation, Protein targeting to Nucleus, Dicarboxylic Acid Transport