RAF1 Antikörper (V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1) (pSer338)

Details for Product anti-RAF1 Antibody No. ABIN119063, Anbieter: Anmelden zum Anzeigen
Antigen
  • c-raf
  • craf
  • raf1
  • RAF1
  • raf
  • CRAF
  • NS5
  • Raf-1
  • c-Raf
  • 6430402F14Rik
  • AA990557
  • BB129353
  • Craf1
  • D830050J10Rik
  • v-Raf
  • AFR1
  • RAF
  • Afr-1
  • Afr1
  • Raf
  • mKIAA0854
  • v-raf-1 murine leukemia viral oncogene homolog 1a
  • v-raf-1 murine leukemia viral oncogene homolog 1
  • raf protein
  • v-raf-leukemia viral oncogene 1
  • zinc fingers and homeoboxes 2
  • raf1a
  • RAF1
  • raf1
  • LOC100341921
  • LOC100347407
  • c-raf
  • Raf1
  • ZHX2
  • Zhx2
Epitop
pSer338
79
73
47
47
46
43
41
34
34
28
27
21
21
19
18
17
15
15
15
15
15
12
7
7
7
6
6
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
835
413
388
25
23
16
16
13
8
8
8
5
4
4
2
2
1
1
1
Wirt
Ratte
781
63
11
6
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser RAF1 Antikörper ist unkonjugiert
45
45
44
30
29
29
14
14
12
12
12
12
12
12
12
12
12
2
2
2
2
2
2
2
2
2
1
1
Applikation
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
512
365
221
172
156
103
52
49
20
18
18
7
2
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Synthetic peptide GQRDpSSYpYWEIEAS coupled to glutaraldehyde.
Klon P5338 (DPR-2-2A-3A)
Isotyp IgG1
Spezifität This antibody recognises activated Raf-1, binding to the phosphorylated serine residue at position 338. The antibody binds to Raf-1 that has been activated by Ras or Src, but not to unactivated Raf-1. The antibody does not bind to Raf peptides phosphorylated at other sites, including Y341 and S339.
Reinigung Affinity chromatography on Protein G
Andere Bezeichnung RAF1 (RAF1 Antibody Abstract)
Hintergrund Synonyms: C-RAF, RAF proto-oncogene serine/threonine-protein kinase, Raf-1, cRaf
Gen-ID 5894
NCBI Accession NP_002871
UniProt P04049
Forschungsgebiet Signaling, Kinases/Phosphatases
Pathways MAPK Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, Neurotrophin Signalübertragung, cAMP Metabolic Process, Stem Cell Maintenance, Hepatitis C, Autophagie, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
Applikationshinweise Western Blot: 1/100 - 1/1000, This antibody may be used for Western blotting detection of activated Raf-1 as described by Mason et al. (1999).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1.0 mg/mL
Buffer PBS, pH 7.4 containing 0.09 % Sodium Azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1) (pSer338) antibody (ABIN119063) Formalin-fixed, paraffin-embedded human tonsil stained with SM1489 (Note nuclear stai...
Allgemeine Veröffentlichungen Mason, Springer, Cooper, Superti-Furga, Marshall, Marais: "Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation." in: The EMBO journal, Vol. 18, Issue 8, pp. 2137-48, 1999 (PubMed).

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