Myelin Basic Protein (MBP) (AA 84-89) Antikörper

Details zu Produkt Nr. ABIN119023, Anbieter: Anmelden zum Anzeigen
Antigen
  • cb274
  • fj33b11
  • mbp
  • wu:fj33b11
  • wu:fq15b02
  • zgc:136630
  • MGC115135
  • Mbps
  • C76307
  • Hmbpr
  • R75289
  • golli-mbp
  • mld
  • shi
  • myelin basic protein a
  • myelin basic protein
  • myelin basic protein L homeolog
  • mbpa
  • mbp
  • mbp.L
  • MBP
  • Mbp
Epitop
AA 84-89
15
11
7
6
6
6
5
5
4
4
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Säugetier
154
49
41
39
15
14
13
11
5
5
5
4
4
4
3
2
2
1
Wirt
Maus
90
68
14
9
1
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
5
5
4
3
3
2
1
Applikation
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
121
78
62
40
30
24
23
14
12
7
7
6
6
4
3
3
1
Optionen
Hersteller
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Immunogen Human myelin basic protein. Spleen cells from immunised mice were fused with cells of the mouse SP2/0 myeloma cell line.
Klon 22
Isotyp IgG2b
Spezifität This antibody recognises an epitope of Human myelin basic protein between amino acids 84-89. Reacts with MBP from most species.
Reinigung Supernatant
Andere Bezeichnung Myelin Basic Protein (MBP Antibody Abstract)
Hintergrund The classic group of Myelin basic protein (MBP) isoforms (isoforms 4 to 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non classic group of MBP isoforms (isoforms 1 to 3/Golli MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T cells and neural cells. Differential splicing events combined to optional posttranslational modifications give a wide spectrum of isomers, each of them having maybe a specialized function.Synonyms: MBP, Myelin membrane encephalitogenic protein
Gen-ID 4155
NCBI Accession NP_001020252
UniProt P02686
Forschungsgebiet Glia marker, Cell/Tissue Markers
Applikationshinweise Immunohistochemistry on frozen sections. Immunohistochemistry on paraffin sections. Recommended positive control: Brain. Has been reported to work in Western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer 0.09 % Sodium Azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Myelin Basic Protein (MBP) (AA 84-89) antibody (ABIN119023) Staining of white matter in human brain with Mouse anti MBP
Allgemeine Veröffentlichungen Liao, Ahmed, Smith, Van Nostrand: "Degradation of amyloid beta protein by purified myelin basic protein." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28917-25, 2009 (PubMed).

Harrower, Tyers, Hooks, Barker: "Long-term survival and integration of porcine expanded neural precursor cell grafts in a rat model of Parkinson's disease." in: Experimental neurology, Vol. 197, Issue 1, pp. 56-69, 2005 (PubMed).

Groome, Dawkes, Barry, Hruby, Alvord: "New monoclonal antibodies reactive with defined sequential epitopes in human myelin basic protein." in: Journal of neuroimmunology, Vol. 19, Issue 4, pp. 305-15, 1988 (PubMed).

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