ITGA2 Antikörper (PE)

Produktnummer ABIN118701

Produktdetails anti-ITGA2 Antikörper (PE)

Target: ITGA2 (Integrin alpha 2 (ITGA2))

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ITGA2 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Spezifität: Recognizes the Integrin alpha 2 subunit (CD49b), which is a 160 kDa glycoprotein that non-covalently associates with the 130 kDa integrin beta1 subunit to form the VLA-2 complex.

Aufreinigung: Affinity Chromatography on Protein G

Klon: AK7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: Use 10 μL of neat antibody to label 10^6 cells or 100 μL human whole blood.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 1.0 mL distilled water.

Buffer: PBS, pH 7.2 with 0.09 % Sodium Azide as preservative, 1 % BSA and 5 % Sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Prior to and following reconstitution store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Details zu ITGA2

Target: ITGA2 (Integrin alpha 2 (ITGA2))

Andere Bezeichnung: CD49b / ITGA2 (ITGA2 Produkte)

Synonyme: BR antikoerper, CD49B antikoerper, GPIa antikoerper, HPA-5 antikoerper, VLA-2 antikoerper, VLAA2 antikoerper, DX5 antikoerper, integrin subunit alpha 2 antikoerper, integrin alpha 2 antikoerper, ITGA2 antikoerper, Itga2 antikoerper

Hintergrund: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. CD49b is a 160kD glycoprotein that non-covalently associates with the 130kD integrin beta 1 subunit to form the VLA-2 complex. CD49b is expressed by platelets, long term cultivated T cells, approximately 50 % of monocytes and most adherent cell lines.Synonyms: CD49 antigen-like family member B, Collagen Receptor, GPIa, ITGA-2, Integrin alpha-2, Platelet membrane glycoprotein Ia, VLA-2 alpha, VLA2

Gen-ID: 3673

NCBI Accession: NP_002194

UniProt: P17301

Pathways: CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex