CD47 Antikörper

Produktnummer ABIN1177375

Produktdetails anti-CD47 Antikörper

Target: CD47

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD47 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Klon: B6H12

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-CD47 Antikörper (ABIN1177375)

Lindberg, Lublin, Telen, Veile, Miller, Donis-Keller, Brown: "Rh-related antigen CD47 is the signal-transducer integrin-associated protein." in: The Journal of biological chemistry, Vol. 269, Issue 3, pp. 1567-70, (1994) (PubMed).

Brown, Hooper, Ho, Gresham: "Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins." in: The Journal of cell biology, Vol. 111, Issue 6 Pt 1, pp. 2785-94, (1991) (PubMed).

Details zu CD47

Target: CD47

Andere Bezeichnung: CD47 (IAP) (CD47 Produkte)

Synonyme: IAP antikoerper, MER6 antikoerper, OA3 antikoerper, 9130415E20Rik antikoerper, AA407862 antikoerper, AI848868 antikoerper, AW108519 antikoerper, B430305P08Rik antikoerper, Itgp antikoerper, CD47/IAP antikoerper, alkaline phosphatase, intestinal antikoerper, CD47 molecule antikoerper, CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antikoerper, Cd47 molecule antikoerper, ALPI antikoerper, CD47 antikoerper, Cd47 antikoerper

Hintergrund: The B6H12 monoclonal antibody specifically binds to a 42-52 kDa N-linked glycan protein. CD47 antigen, also known as integrin-associated protein (IAP), is expressed on all hematopoietic cells, including leukocytes, platelets and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts and many tumor cell lines. CD47 may play a role as a signal transducer in the regulation of cation fluxes across cell membranes and in the chemotactic and adhesive interactions of leukocytes with endothelial cells. The B6H12 antibody is capable of blocking phagocytosis of microparticles by peripheral blood granulocytes. It has also been reported to induce proliferation of CD3-activated T cells.
Synonyms: IAP, CDw149, gp42, MER6, Neurophilin, OA3 , Rh-related antigen