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PTK2B Antikörper (pTyr402) (PE)

PTK2B Reaktivität: Human, Maus, Ratte ICS Wirt: Maus Monoclonal L68-1256-272 PE
Produktnummer ABIN1177156
  • Target Alle PTK2B Antikörper anzeigen
    PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
    Bindungsspezifität
    • 24
    • 22
    • 17
    • 15
    • 10
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr402
    Reaktivität
    • 116
    • 115
    • 97
    • 8
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 146
    • 14
    • 3
    Maus
    Klonalität
    • 141
    • 22
    Monoklonal
    Konjugat
    • 76
    • 11
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    Dieser PTK2B Antikörper ist konjugiert mit PE
    Applikation
    • 124
    • 59
    • 44
    • 40
    • 39
    • 26
    • 13
    • 13
    • 9
    • 4
    • 1
    • 1
    • 1
    Intracellular Staining (ICS)
    Marke
    BD Phosflow™
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Phosphorylated Human Pyk2 Peptide
    Klon
    L68-1256-272
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product PTK2B Primärantikörper
  • Applikationshinweise
    Either BD Cytofix™ fixation buffer or BD™ Phosflow Fix Buffer I may be used for cell fixation. Any of the three BD™ Phosflow permeabilization buffers may be used.
    Kommentare

    BALB/c

    Probenmenge
    20 μL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed. Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
  • Anand, Cucchiarini, Terwilliger, Ganju: "The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 8, pp. 5636-44, (2008) (PubMed).

    Faure, Corvol, Toutant, Valjent, Hvalby, Jensen, El Messari, Corsi, Kadaré, Girault: "Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons." in: Journal of cell science, Vol. 120, Issue Pt 17, pp. 3034-44, (2007) (PubMed).

    Orr, Murphy-Ullrich: "Regulation of endothelial cell function BY FAK and PYK2." in: Frontiers in bioscience : a journal and virtual library, Vol. 9, pp. 1254-66, (2004) (PubMed).

    Park, Avraham, Avraham: "RAFTK/Pyk2 activation is mediated by trans-acting autophosphorylation in a Src-independent manner." in: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33315-22, (2004) (PubMed).

    Gluck: "Acid sensing in renal epithelial cells." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1696-9, (2004) (PubMed).

    Avraham, Park, Schinkmann, Avraham: "RAFTK/Pyk2-mediated cellular signalling." in: Cellular signalling, Vol. 12, Issue 3, pp. 123-33, (2000) (PubMed).

  • Target
    PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
    Andere Bezeichnung
    Pyk2 (PTK2B Produkte)
    Synonyme
    CADTK antikoerper, CAKB antikoerper, FADK2 antikoerper, FAK2 antikoerper, PKB antikoerper, PTK antikoerper, PYK2 antikoerper, RAFTK antikoerper, CAKbeta antikoerper, E430023O05Rik antikoerper, Raftk antikoerper, Pyk2 antikoerper, fak1b antikoerper, ptk2.2 antikoerper, ptk2b antikoerper, si:ch1073-355e8.1 antikoerper, protein tyrosine kinase 2 beta antikoerper, PTK2 protein tyrosine kinase 2 beta antikoerper, protein tyrosine kinase 2aa antikoerper, PTK2B antikoerper, Ptk2b antikoerper, ptk2aa antikoerper
    Hintergrund
    Proline-rich tyrosine kinase 2 (Pyk2) is a member of the FAK subfamily of tyrosine protein kinases. Pyk2 responds to a wide variety of inflammatory and stress stimuli, such as cytokines, ligation of integrins or antigen receptors, mechanical strain, and cellular depolarization. A common characteristic of most Pyk2 stimuli is an increase in cytosolic free calcium. Pyk2 is involved in signaling pathways that regulate vital cellular functions in hematopoietic, epithelial, neuronal, endothelial, and other cell types. Activation of Pyk2 initiates its autophosphorylation at tyrosine 402 (Y402), followed by Src-mediated phosphorylation of other Pyk2 tyrosine sites, which enhances its activity and leads to downstream signal transduction through the MAPK and JNK pathways. The L68-1256.272 monoclonal antibody recognizes the phosphorylated Y402 of activated Pyk2.
    Synonyms: Protein tyrosine kinase 2beta, FAK2, FADK 2, CAKbeta, CADTK, RAFTK
    Pathways
    EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
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