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MAPKAP Kinase 2 Antikörper (pThr334) (Alexa Fluor 488)

MAPKAPK2 Reaktivität: Human, Maus ICS Wirt: Maus Monoclonal P24-694 Alexa Fluor 488
Produktnummer ABIN1177089
  • Target Alle MAPKAP Kinase 2 (MAPKAPK2) Antikörper anzeigen
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    Bindungsspezifität
    • 38
    • 25
    • 19
    • 16
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr334
    Reaktivität
    • 109
    • 95
    • 94
    • 21
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 134
    • 6
    • 2
    Maus
    Klonalität
    • 120
    • 22
    Monoklonal
    Konjugat
    • 61
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Dieser MAPKAP Kinase 2 Antikörper ist konjugiert mit Alexa Fluor 488
    Applikation
    • 91
    • 43
    • 40
    • 39
    • 33
    • 24
    • 19
    • 13
    • 9
    • 8
    • 8
    • 3
    • 3
    • 1
    • 1
    Intracellular Staining (ICS)
    Marke
    BD Phosflow™
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Phosphorylated Human MAPKAPK-2 Peptide
    Klon
    P24-694
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product MAPKAPK2 Primärantikörper
  • Probenmenge
    5 μL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated to Alexa Fluor® 488 under optimum conditions, and unreacted Alexa Fluor® 488 was removed.
  • Manke, Nguyen, Lim, Stewart, Elia, Yaffe: "MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation." in: Molecular cell, Vol. 17, Issue 1, pp. 37-48, (2005) (PubMed).

    Wang, Xu, Wang, Young, Gaestel, Feuerstein: "Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice." in: The Journal of biological chemistry, Vol. 277, Issue 46, pp. 43968-72, (2002) (PubMed).

    Heidenreich, Neininger, Schratt, Zinck, Cahill, Engel, Kotlyarov, Kraft, Kostka, Gaestel, Nordheim: "MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo." in: The Journal of biological chemistry, Vol. 274, Issue 20, pp. 14434-43, (1999) (PubMed).

    Engel, Kotlyarov, Gaestel: "Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation." in: The EMBO journal, Vol. 17, Issue 12, pp. 3363-71, (1998) (PubMed).

    Krump, Sanghera, Pelech, Furuya, Grinstein: "Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils." in: The Journal of biological chemistry, Vol. 272, Issue 2, pp. 937-44, (1997) (PubMed).

    Ben-Levy, Leighton, Doza, Attwood, Morrice, Marshall, Cohen: "Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2." in: The EMBO journal, Vol. 14, Issue 23, pp. 5920-30, (1996) (PubMed).

    Clifton, Young, Cohen: "A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress." in: FEBS letters, Vol. 392, Issue 3, pp. 209-14, (1996) (PubMed).

    Rouse, Cohen, Trigon, Morange, Alonso-Llamazares, Zamanillo, Hunt, Nebreda: "A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins." in: Cell, Vol. 78, Issue 6, pp. 1027-37, (1994) (PubMed).

  • Target
    MAPKAP Kinase 2 (MAPKAPK2) (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2))
    Andere Bezeichnung
    MAPKAPK-2 (MAPKAPK2 Produkte)
    Synonyme
    mapkapk2 antikoerper, wu:fb30e10 antikoerper, wu:fc56c10 antikoerper, wu:fi03a01 antikoerper, MGC78852 antikoerper, MAPKAPK2 antikoerper, AA960234 antikoerper, MAPKAP-K2 antikoerper, MK-2 antikoerper, MK2 antikoerper, Rps6kc1 antikoerper, mitogen-activated protein kinase-activated protein kinase 2a antikoerper, mitogen-activated protein kinase-activated protein kinase 2 L homeolog antikoerper, mitogen-activated protein kinase-activated protein kinase 2 antikoerper, MAP kinase-activated protein kinase 2 antikoerper, mapkapk2a antikoerper, mapkapk2.L antikoerper, MAPKAPK2 antikoerper, Mapkapk2 antikoerper
    Hintergrund
    The P24-694 monoclonal antibody specifically binds to the phosphorylated T334 site (pT334) of MAPKAPK-2. MAPKAPK-2 is a serine/threonine protein kinase. This ~49 kDa member of the MAPKAPK family of protein kinases is also known as mitogen-activated protein kinase-activated protein kinase 2. MAPKAPK-2 is phosphorylated and activated by p38 MAP kinase in response to stress, cytokines and chemokines. MAPKAPK-2 is phosphorylated on multiple sites including Thr222, Ser272 and Thr334. Phosphorylation of any two of these three amino acid residues seems to be required for the activation of this kinase that serves multiple cellular functions. Phosphorylation of Thr334 was reported to be essential for nuclear export of the heterodimer formed between p38 MAPK and MAPKAPK-2. Mice deficient in MAPKAPK-2 have been shown to be protected from ischemic injury. MAPKAPK-2 is also reported to serve as a cell cycle checkpoint kinase in response to UV irradiation. The heat shock protein, HSP27 was shown to be one of the major substrates of MAPK and MAPKAPK-2.
    Synonyms: MAP kinase-activated protein kinase 2, MAPKAP kinase 2, MK2, MAPK2
    Pathways
    MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades
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