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IKBKG Antikörper (pSer376) (PE)

IKBKG Reaktivität: Human ICS Wirt: Maus Monoclonal N19-39 PE
Produktnummer ABIN1177069
  • Target Alle IKBKG Antikörper anzeigen
    IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
    Bindungsspezifität
    • 28
    • 16
    • 13
    • 12
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer376
    Reaktivität
    • 137
    • 49
    • 43
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    Human
    Wirt
    • 121
    • 19
    • 2
    Maus
    Klonalität
    • 115
    • 27
    Monoklonal
    Konjugat
    • 78
    • 8
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser IKBKG Antikörper ist konjugiert mit PE
    Applikation
    • 89
    • 50
    • 28
    • 27
    • 26
    • 24
    • 22
    • 18
    • 10
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    Intracellular Staining (ICS)
    Marke
    BD Phosflow™
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Phosphorylated Human IKKgamma Peptide
    Klon
    N19-39
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product IKBKG Primärantikörper
  • Probenmenge
    5 μL
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Aqueous buffered solution containing BSA and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze. The antibody was conjugated with R-PE under optimum conditions, and unconjugated antibody and free PE were removed.
  • Shifera: "The zinc finger domain of IKKγ (NEMO) protein in health and disease." in: Journal of cellular and molecular medicine, Vol. 14, Issue 10, pp. 2404-14, (2010) (PubMed).

    Carter, Pennington, Ungurait, Ballard: "In vivo identification of inducible phosphoacceptors in the IKKgamma/NEMO subunit of human IkappaB kinase." in: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 19642-8, (2003) (PubMed).

    Ling, Cao, Goeddel: "NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 7, pp. 3792-7, (1998) (PubMed).

    Rothwarf, Zandi, Natoli, Karin: "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex." in: Nature, Vol. 395, Issue 6699, pp. 297-300, (1998) (PubMed).

    DiDonato, Hayakawa, Rothwarf, Zandi, Karin: "A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB." in: Nature, Vol. 388, Issue 6642, pp. 548-54, (1997) (PubMed).

    Mercurio, Zhu, Murray, Shevchenko, Bennett, Li, Young, Barbosa, Mann, Manning, Rao: "IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation." in: Science (New York, N.Y.), Vol. 278, Issue 5339, pp. 860-6, (1997) (PubMed).

  • Target
    IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
    Abstract
    IKBKG Produkte
    Synonyme
    AMCBX1 antikoerper, FIP-3 antikoerper, FIP3 antikoerper, Fip3p antikoerper, IKK-gamma antikoerper, IP antikoerper, IP1 antikoerper, IP2 antikoerper, IPD2 antikoerper, NEMO antikoerper, ZC2HC9 antikoerper, 1110037D23Rik antikoerper, AI848108 antikoerper, AI851264 antikoerper, AW124339 antikoerper, IKK[g] antikoerper, Nemo antikoerper, nemo antikoerper, fj33c07 antikoerper, wu:fj33c07 antikoerper, zgc:113492 antikoerper, MGC97885 antikoerper, IKBKG antikoerper, IKBKG_1 antikoerper, IKBKG_2 antikoerper, CG16910 antikoerper, DmIKK-gamma antikoerper, DmIKKgamma antikoerper, Dmel\\CG16910 antikoerper, Dmikkgamma antikoerper, IKK antikoerper, IKK[[gamma]] antikoerper, IKKg antikoerper, IKKgamma antikoerper, KEY antikoerper, Kenny antikoerper, Key antikoerper, dIKK antikoerper, dIKK-gamma antikoerper, dmIKKgamma antikoerper, inhibitor of nuclear factor kappa B kinase subunit gamma antikoerper, inhibitor of kappaB kinase gamma antikoerper, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma antikoerper, inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog antikoerper, kenny antikoerper, IKBKG antikoerper, Ikbkg antikoerper, ikbkg antikoerper, ikbkg.L antikoerper, IKBKG_1 antikoerper, key antikoerper
    Hintergrund
    The N19-39 monoclonal antibody specifically binds to the IKK-gamma protein phosphorylated at the Ser376 site, ie, IKKgamma (pS376). IKKgamma is also known an NEMO (NF-kappa-B essential modifier) and is encoded by the IKBKG (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma) gene. The nuclear transcription factor kappa-B, NF-kappaB, is controlled by interaction with an inhibitory subunit, IkappaB, which restricts NF-kappaB to the cytoplasm. Following stimulation by various cytokines or other stimuli, IkappaB becomes degraded and NF-kappaB is released to the nucleus. The release of IkappaB from NF-kappaB is thought to be a critical point in the activation of NF-kappaB signal pathways. Activated NF-kappaB regulates genes involved in various pathways including inflammation, immunity, and cell survival signaling pathways. A group of proteins form an NF-kappaB regulatory complex, or signalsome. Two members of this complex are a pair of closely related serine/threonine kinases, IKKalpha and IKKbeta (also called IKK-1 and IKK-2), which phosphorylate critical residues of IkappaB, thus targeting it for subsequent degradation. The IKK complex contains similar amounts of IKKalpha, IKKbeta as well as two other polypeptides, which are differentially processed forms of a third subunit, IKKgamma. IKKalpha and IKKbeta become activated following phosphorylation by upstream kinases, including NF-kappaB-inducing kinase (NIK)4 and MEKK1. IKKbeta has been shown to phosphorylate IKKgamma at serine 376 in response to signaling through the TNF receptor or the Tax oncoprotein of human T-cell leukemia virus type 1. IKKgamma has an essential regulatory role in the IKK complex and is required for the activation of the NF-kappaB pathway in response to multiple cellular stimuli. IKKgamma isoforms migrate as a doublet of ~50-55 kDa upon Western blot analysis.
    Synonyms: IKBKG, IKKgamma, IKKG, IKK-gamma, AMCBX1, FIP3, IKKAP1, IP1, IP2, IPD2, NEMO
    Pathways
    NF-kappaB Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, M Phase, Production of Molecular Mediator of Immune Response, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteine
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