CD48 Antikörper
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- Target Alle CD48 Antikörper anzeigen
- CD48
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Reaktivität
- Maus
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Wirt
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Armenischer Hamster
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD48 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Blocking Reagent (BR)
- Marke
- BD Pharmingen™
- Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Sterilität
- 0.2 μm filtered
- Endotoxin-Niveau
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- Immunogen
- Mouse T lymphoma MBL-2
- Klon
- HM48-1
- Isotyp
- IgG1 lambda
- Top Product
- Discover our top product CD48 Primärantikörper
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1.0 mg/mL
- Buffer
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- Konservierungsmittel
- Azide free
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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Identification of the 2B4 molecule as a counter-receptor for CD48." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 5809-12, (1998) (PubMed).
: "Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival." in: The Journal of experimental medicine, Vol. 179, Issue 1, pp. 341-6, (1994) (PubMed).
: "CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1241-9, (1992) (PubMed).
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Identification of the 2B4 molecule as a counter-receptor for CD48." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 5809-12, (1998) (PubMed).
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- Target
- CD48
- Andere Bezeichnung
- CD48 (BCM1) (CD48 Produkte)
- Synonyme
- AI449234 antikoerper, AW610730 antikoerper, BCM1 antikoerper, BLAST antikoerper, BLAST-1 antikoerper, BLAST1 antikoerper, Bcm-1 antikoerper, MEM-102 antikoerper, SLAMF2 antikoerper, Sgp-60 antikoerper, hCD48 antikoerper, mCD48 antikoerper, CD48 antigen antikoerper, Cd48 molecule antikoerper, CD48 molecule antikoerper, Cd48 antikoerper, CD48 antikoerper
- Hintergrund
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The HM48-1 monoclonal antibody specifically binds to CD48 (previously known as BCM1 in mice, Blast-1 in human, and OX-45 in the rat), a GPI-anchored member of the Ig superfamily. It is widely distributed on leukocytes, but not on non-hematopoietic cells, and its ligands include CD2 (LFA-2) and CD244 (2B4 antigen). The HM48-1 mAb blocks binding of soluble CD2 to CD48-bearing cells, blocks the interaction of CD2 and CD244, inhibits spleen cell proliferative responses to mitogens, augments the proliferative response of spleen cells when cross-linked with anti-CD3e mAbs, and inhibits priming of CTL in vitro. In vivo administration of HM48-1 antibody can prolong survival of cardiac allografts, an effect which is greatly enhanced by the addition of anti-CD2 mAb 12-15. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.
Synonyms: BLAST, BLAST-1, BCM1, HM48-1, MEM-102, Sgp-60, SLAMF2
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