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CD48 Antikörper

CD48 Reaktivität: Maus FACS, WB, IP, Func, BR Wirt: Armenischer Hamster Monoclonal HM48-1 unconjugated
Produktnummer ABIN1177003
  • Target Alle CD48 Antikörper anzeigen
    CD48
    Reaktivität
    • 89
    • 56
    • 14
    • 6
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 58
    • 35
    • 16
    • 14
    • 6
    Armenischer Hamster
    Klonalität
    • 93
    • 33
    Monoklonal
    Konjugat
    • 50
    • 13
    • 12
    • 11
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD48 Antikörper ist unkonjugiert
    Applikation
    • 86
    • 43
    • 21
    • 18
    • 15
    • 15
    • 14
    • 6
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Blocking Reagent (BR)
    Marke
    BD Pharmingen™
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Immunogen
    Mouse T lymphoma MBL-2
    Klon
    HM48-1
    Isotyp
    IgG1 lambda
    Top Product
    Discover our top product CD48 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Latchman, McKay, Reiser: "Identification of the 2B4 molecule as a counter-receptor for CD48." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 11, pp. 5809-12, (1998) (PubMed).

    Qin, Chavin, Lin, Yagita, Bromberg: "Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival." in: The Journal of experimental medicine, Vol. 179, Issue 1, pp. 341-6, (1994) (PubMed).

    Kato, Koyanagi, Okada, Takanashi, Wong, Williams, Okumura, Yagita: "CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1241-9, (1992) (PubMed).

  • Target
    CD48
    Andere Bezeichnung
    CD48 (BCM1) (CD48 Produkte)
    Synonyme
    AI449234 antikoerper, AW610730 antikoerper, BCM1 antikoerper, BLAST antikoerper, BLAST-1 antikoerper, BLAST1 antikoerper, Bcm-1 antikoerper, MEM-102 antikoerper, SLAMF2 antikoerper, Sgp-60 antikoerper, hCD48 antikoerper, mCD48 antikoerper, CD48 antigen antikoerper, Cd48 molecule antikoerper, CD48 molecule antikoerper, Cd48 antikoerper, CD48 antikoerper
    Hintergrund
    The HM48-1 monoclonal antibody specifically binds to CD48 (previously known as BCM1 in mice, Blast-1 in human, and OX-45 in the rat), a GPI-anchored member of the Ig superfamily. It is widely distributed on leukocytes, but not on non-hematopoietic cells, and its ligands include CD2 (LFA-2) and CD244 (2B4 antigen). The HM48-1 mAb blocks binding of soluble CD2 to CD48-bearing cells, blocks the interaction of CD2 and CD244, inhibits spleen cell proliferative responses to mitogens, augments the proliferative response of spleen cells when cross-linked with anti-CD3e mAbs, and inhibits priming of CTL in vitro. In vivo administration of HM48-1 antibody can prolong survival of cardiac allografts, an effect which is greatly enhanced by the addition of anti-CD2 mAb 12-15. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leukocytes.
    Synonyms: BLAST, BLAST-1, BCM1, HM48-1, MEM-102, Sgp-60, SLAMF2
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